| Cat. # | Size | Price | Inventory |
|---|---|---|---|
| 16537S | 1 Kit |
| REACTIVITY | H |
| Product Includes | Quantity | Isotype | |||
|---|---|---|---|---|---|
| CD31 (PECAM-1) (89C2) Mouse mAb (BSA and Azide Free) 85873 | 100 µg | Mouse IgG1 | |||
| CD31 (PECAM-1) (158-2B3) Mouse mAb (BSA and Azide Free) | 100 µg | Mouse IgG1 |
Product Information
CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3).
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