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PTMScan® Direct 丝氨酸/苏氨酸激酶蛋白质组服务

PTMScan® Direct Ser/Thr Kinases Service 允许对丝氨酸/苏氨酸激酶组内一组确定的蛋白质位点进行靶向筛选和定量分析,而且该组蛋白质位点对药物发现、生物标记物发现或诊断学发展至关重要。PTMScan Direct Ser/Thr Kinases Service 能够对丝氨酸/苏氨酸磷酸化进行全激酶组评估。下表列出了可使用 PTMScan® Direct Ser/Thr Kinases Service 进行监测的蛋白质位点列表。

总而言之,PTMScan® Direct Ser/Thr Kinases 服务提供了一种可定性识别和定量分析 130 个蛋白质的 385 个特有的磷酸化位点的稳健方法。

人类激酶组中的高亮丝氨酸/苏氨酸节点

丝氨酸/苏氨酸蛋白质位点
丝氨酸/苏氨酸蛋白质位点
β-Actin* Akt1 (Ser473) Akt1 (Ser475) Akt1 (Thr305)
Akt1 (Thr308) Akt1 (Thr312) Akt1 (Thr479) Akt1 (Tyr315)
Akt1 (Tyr474) Akt2 (Ser302) Akt2 (Ser474) Akt2 (Ser476)
Akt2 (Ser478) Akt2 (Thr306) Akt2 (Thr309) Akt2 (Thr313)
Akt2 (Tyr316) Akt2 (Tyr475) Akt3 (Ser472) Akt3 (Ser474)
Akt3 (Ser476) Akt3 (Thr302) Akt3 (Thr305) Akt3 (Thr309)
Akt3 (Tyr473) AMPKα1 (Ser172) AMPKα1 (Ser176) AMPKα1 (Ser184)
AMPKα1 (Ser187) AMPKα1 (Ser486) AMPKα1 (Ser494) AMPKα1 (Ser496)
AMPKα1 (Thr183) AMPKα1 (Thr482) AMPKα1 (Thr488) AMPKα1 (Thr490)
AMPKα2 (Ser161) AMPKα2 (Ser165) AMPKα2 (Ser173) AMPKα2 (Ser176)
AMPKα2 (Thr172) ASK1 (Thr916) ASK1 (Thr918) ATM (Ser1981)
ATM (Ser1983) Aurora A (Thr287) Aurora A (Thr288) Aurora A (Thr292)
Aurora B (Thr232) Aurora B (Thr236) Aurora C (Thr198) Aurora C (Thr202)
Bcr (Tyr177) BMPR2 (Thr977) BMPR2 (Tyr979) Brd2 (Ser253)
Brd2 (Ser256) Brd4 (Thr942) CDK1 (Thr14) CDK1 (Tyr15)
CDK1 (Tyr19) CDK2 (Thr14) CDK2 (Tyr15) CDK2 (Tyr19)
CDK3 (Thr14) CDK3 (Tyr15) CDK3 (Tyr19) CDK5 (Tyr15)
CDK6 (Tyr24) ChaK1 (Ser1404) ChaK1 (Ser1407) CHED (Ser1225)
CHED (Ser1229) CHED (Thr1226) Chk1 (Ser296) Chk1 (Ser305)
Chk1 (Ser307) Chk1 (Ser315) Chk1 (Ser316) Chk1 (Ser317)
Chk1 (Ser343) Chk1 (Ser345) Chk1 (Ser357) Chk1 (Thr348)
Chk1 (Thr362) Chk1 (Tyr314) CKB (Thr35) CLK3 (Ser157)
CLK3 (Ser165) CLK3 (Tyr155) CLK3 (Tyr163) CLK3 (Tyr166)
CRK7 (Thr1244) CRK7 (Thr1246) dCK (Ser13) Erk1 (Thr202)
Erk1 (Thr207) Erk1 (Tyr204) Erk2 (Thr185) Erk2 (Thr190)
Erk2 (Tyr187) Erk3 (Ser363) Erk3 (Tyr357) Erk5 (Thr218)
Erk5 (Tyr220) GAPDH* GCN2 (Ser254) GCN2 (Ser258)
GCN2 (Ser261) GCN2 (Ser264) GCN2 (Ser274) GCN2 (Tyr253)
GCN2 (Tyr269) GSK-3α (Ser20) GSK-3α (Ser21) GSK-3α (Thr19)
GSK-3β (Ser13) GSK-3β (Ser25) GSK-3β (Ser9) GSK-3β (Thr8)
HGK (Ser264) HGK (Thr187) HKDC1 (Ser155) HKDC1 (Thr153)
Histone H3* ICK (Thr157) ICK (Tyr159) IKKε (Ser172)
KSR (Ser265) KSR (Thr268) KSR (Thr272) KSR2 (Thr269)
KSR2 (Thr276) LOC100133591 (Ser223) LOC651610 (Ser1859) LOC651610 (Ser1861)
LRRK1 (Thr30) LRRK2 (Ser961) MAPKAPK-2 (Thr221) MAPKAPK-2 (Thr222)
MAPKAPK-2 (Thr317) MAPKAPK-2 (Thr329) MAPKAPK-2 (Thr334) MAPKAPK-2 (Thr338)
MAPKAPK-2 (Tyr225) MAPKAPK-3 (Ser307) MAPKAPK-3 (Thr313) MAPKAPK-3 (Thr317)
MARK1 (Thr504) MARK2 (Ser592) MARK2 (Ser593) MARK2 (Ser595)
MARK2 (Thr596) MARK3 (Thr530) MEK1 (Ser218) MEK1 (Ser222)
MEK1 (Thr226) MEK2 (Ser222) MEK2 (Ser226) MEK2 (Thr230)
MINK (Thr187) MKK3 (Ser212) MKK3 (Ser218) MKK3 (Ser253)
MKK3 (Thr222) MKK3 (Tyr214) MKK3 (Tyr230) MKK4 (Ser257)
MKK4 (Thr261) MKK6 (Ser201) MKK6 (Ser207) MKK6 (Thr211)
MSK1 (Ser376) MSK1 (Ser381) MSK1 (Tyr375) MSK2 (Ser360)
MSK2 (Ser365) MSK2 (Ser634) MSK2 (Thr376) MSK2 (Tyr359)
Mst1 (Ser40) Mst1 (Ser43) Mst1 (Tyr41) Mst3 (Thr182)
Mst3 (Thr184) Mst3 (Thr190) Mst3 (Thr194) Mst4 (Thr178)
Mst4 (Thr182) mTOR (Ser178) mTOR (Ser2442) mTOR (Ser2448)
mTOR (Ser2450) mTOR (Ser2454) mTOR (Thr2444) mTOR (Thr2446)
mTOR (Tyr2449) NDK7 (Ser304) NDK7 (Thr300) NDK7 (Thr318)
NDK7 (Tyr303) NDR1 (Thr444) NDR1 (Tyr445) NDR2 (Thr442)
NDR2 (Tyr443) OSR1 (Thr185) OSR1 (Thr189) p38α (Thr175)
p38α (Thr180) p38α (Tyr182) p38γ (Thr183) p38γ (Tyr185)
p38δ (Thr180) p38δ (Tyr182) p70 S6 Kinase (Ser243) p70 S6 Kinase (Ser441)
p70 S6 Kinase (Ser447) p70 S6 Kinase (Ser452) p70 S6 Kinase (Thr248) p70 S6 Kinase (Thr250)
p70 S6 Kinase (Thr252) p70 S6 Kinase (Thr444) p70 S6 Kinase β (Ser219) p70 S6 Kinase β (Thr226)
p70 S6 Kinase β (Thr228) p90RSK (Ser221) p90RSK (Ser380) p90RSK (Thr225)
p90RSK (Tyr220) PAK4 (Ser474) PAK4 (Thr207) PAK4 (Thr478)
PAK5 (Ser602) PAK6 (Ser560) PCTAIRE1 (Ser138) PCTAIRE1 (Tyr176)
PCTAIRE2 (Tyr203) PDK1 (Ser241) PDK1 (Thr245) PDK1 (Tyr248)
PDPK2 (Ser214) PDPK2 (Thr218) PDPK2 (Tyr221) PHKA2 (Ser1015)
PHKA2 (Ser1022) PHKA2 (Ser691) PI3 Kinase p110-alpha (Ser507) PITSLRE B (Tyr437)
PITSLRE (Thr595) PITSLRE (Tyr449) PKA C-α (Thr196) PKA C-α (Thr198)
PKA C-α (Thr202) PKA C-β (Thr196) PKA C-β (Thr198) PKA C-β (Thr202)
PKA C-γ (Thr196) PKA C-γ (Thr198) PKA C-γ (Thr202) PKCα (Ser226)
PKCα (Ser657) PKCα (Thr494) PKCα (Thr495) PKCα (Thr497)
PKCα (Thr501) PKCα (Tyr504) PKCβ (Thr497) PKCβ (Thr500)
PKCβ (Thr504) PKCδ (Ser304) PKCδ (Ser506) PKCδ (Ser645)
PKCδ (Ser647) PKCδ (Ser654) PKCδ (Ser658) PKCδ (Ser664)
PKCδ (Thr507) PKCδ (Thr511) PKCδ (Tyr313) PKCδ (Tyr334)
PKCδ (Tyr514) PKCδ (Tyr646) PKCε (Ser729) PKCγ (Thr510)
PKCγ (Thr511) PKCγ (Thr514) PKCγ (Thr518) PKCι (Ser411)
PKCι (Thr409) PKCι (Thr410) PKCι (Thr412) PKCι (Thr416)
PKCθ (Thr307) PKCζ (Ser409) PKCζ (Thr407) PKCζ (Thr410)
PKM2 (Ser77) PKN1 (Ser495) PKN1 (Ser773) PKN1 (Thr772)
PKN1 (Thr774) PKN1 (Tyr768) PKN2 (Ser497) PKN2 (Ser815)
PKN2 (Thr814) PKN2 (Thr816) PKN2 (Thr820) PKN2 (Tyr810)
PKN3 (Thr718) PLK1 (Thr210) PLK1 (Thr214) PRP4 (Ser852)
PRP4 (Tyr849) PRPS1 (Ser314) PRPS1L1 (Ser314) PRPS2 (Ser314)
PYGB (Ser15) PYGB (Tyr263) A-Raf (Ser299) A-Raf (Tyr296)
A-Raf (Tyr301) A-Raf (Tyr302) B-Raf (Ser446) B-Raf (Ser447)
B-Raf (Thr440) Raf1 (Ser338) Raf1 (Ser339) Raf1 (Tyr340)
Raf1 (Tyr341) RIOK2 (Ser332) RIOK2 (Ser335) RIOK2 (Tyr366)
RIPK2 (Ser539) RSK2 (Ser227) RSK2 (Ser386) RSK2 (Thr231)
RSK2 (Tyr226) RSK4 (Ser232) RSK4 (Thr236) RSK4 (Tyr231)
JNK1 (Ser179) JNK1 (Thr183) JNK1 (Thr188) JNK1 (Tyr185)
JNK2 (Thr183) JNK2 (Thr188) JNK2 (Tyr185) JNK3 (Ser217)
JNK3 (Thr221) JNK3 (Thr226) JNK3 (Tyr223) SGK1 (Ser74)
SGK1 (Ser78) SGK1 (Ser80) SGK2 (Thr251) SGK2 (Thr253)
SgK223 (Thr203) SGK3 (Thr320) SGK3 (Thr324) smMLCK (Thr276)
SPEG (Ser378) SPEG (Ser381) SPEG (Thr375) SPAK (Thr233)
SPAK (Thr237) TAO1 (Ser181) TAO1 (Thr185) TAO2 (Ser181)
TAO3 (Ser177) TAO3 (Thr181) TBK1 (Ser172) TIF1β (Ser459)
TIF1β (Ser460) TIF1β (Tyr458) TNIK (Thr187) TTK (Thr33)
α-Tubulin* ULK1 (Ser556) WNK1 (Ser1959) YSK1 (Thr166)
YSK1 (Thr168) YSK1 (Thr174) YSK1 (Thr178) ZAK (Ser591)
ZAK (Ser610) ZAK (Ser648) ZAK (Ser649) ZAK (Thr576)
ZAK (Thr742)      

* 以下靶标被列为总蛋白的对照标准品:β-Actin、Histone H3、GAPDH 与 α-Tubulin。

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