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PTMScan® Direct 细胞周期和 DNA 损伤蛋白质组服务

PTMScan® Direct Cell Cycle and DNA Damage Service 允许对相关 DNA 损伤和细胞周期控制通路内一组确定的蛋白质位点进行靶向筛选和定量分析,而且该组蛋白质位点对药物发现、生物标记物发现或诊断学发展至关重要。下表列出了可使用 PTMScan® Cell Cycle and DNA Damage Service 进行监测的蛋白质位点列表。

总而言之,PTMScan® Direct Cell Cycle and DNA Damage 服务提供了一种可定性识别和定量分析 263 种蛋白质的 168 个特有的磷酸化位点的稳健方法。

PTMScan Direct 细胞周期和 DNA 损伤通路覆盖。

细胞周期和 DNA 损伤蛋白质位点
细胞周期和 DNA 损伤蛋白质位点
53BP1 53BP1 (Ser265) α-tubulin APE1
ATM ATM (Ser1981) ATM (Ser1983) ATR
ATR (Ser428) ATRIP AurA (Thr287) AurA (Thr288)
AurA (Thr292) AurB AurB (Thr232) AurB (Thr236)
AurB (Tyr239) AurC (Thr198) AurC (Thr202) AurC (Tyr205)
β-Actin BLM BLM (Ser74) BRCA2 (Thr77)
Bub3 Bub3 (Ser135) Bub3 (Thr133) CBP
CCND1 (Thr286) CCND1 (Thr288) CCNE1 CCNK iso3
CCNL1 (Ser372) CCNL1 (Ser374) CCNL1 (Tyr376) CCNT1 (Ser626)
CCNYL1 CDC123 Cdc16 Cdc23
Cdc25B Cdc25C Cdc25C (Ser191) Cdc25C (Ser198)
Cdc27 Cdc37 Cdc42 CDC45L
CDCA7 (Thr213) CDK1 CDK1 (Thr14) CDK1 (Tyr15)
CDK1 (Tyr19) CDK10 CDK11 CDK2
CDK2 (Thr14) CDK2 (Tyr15) CDK3 CDK3 (Thr14)
CDK3 (Tyr15) CDK4 CDK5 (Tyr15) CDK6
CDK7 CDK8 CHED (Ser1054) CHED (Ser1065)
CHED (Ser1066) CHED (Thr1056) CHED (Thr1058) Chk1
Chk1 (Ser296) Chk1 (Ser307) Chk1 (Ser308) Chk1 (Ser315)
Chk1 (Ser316) Chk1 (Ser317) Chk1 (Ser345) Chk1 (Ser357)
Chk1 (Thr348) Chk1 (Tyr314) Chk2 Chk2 (Ser379)
DDB1 DNA-PK DNA-PK (Ser3205) ERK1
ERK1 (Thr202) ERK1 (Tyr204) ERK2 ERK2 (Thr185)
ERK2 (Tyr187) ERK5 (Thr219) ERK5 (Tyr221) FANCB
FANCD2 FANCI GAPDH H2AX
H2AX (Ser140) H2AX (Thr137) H3 JNK1 (Thr183)
JNK1 (Tyr185) JNK2 (Thr183) JNK2 (Thr188) JNK2 (Tyr185)
JNK3 (Thr221) JNK3 (Tyr223) Ku70 Ku80
LOC651610 LOC731751 (Ser3204) MCM2 MCM3
MCM4 MCM5 MCM6 MCM7
MKK3 (Ser253) MKK4 (Ser257) MLH1 MRE11A
MSH2 (Ser717) MSH6 (Ser309) MST1 (Ser40) MST1 (Ser43)
Myt1 (Ser40) NBS1 NPM1 (Ser125) NUCKS
NUCKS (Ser14) NUCKS (Ser181) NUCKS (Ser19) NuMA-1
NuMA-1 (Ser1772) NuMA-1 (Ser395) NuMA-1 (Thr1776) p300
p21Cip1 p21Cip1 (Ser130) p27Kip1 p27Kip1 (Ser175)
p27Kip1 (Ser178) p27Kip1 (Ser183) p27Kip1 (Thr170) p27Kip1 (Thr187)
p38α (Ser61) p38α (Thr175) p38α (Thr180) p38α (Tyr182)
p38δ (Thr180) p38δ (Tyr182) p38γ (Ser180) p38γ (Thr183)
p38γ (Tyr185) p53 (Ser392) p70S6K (Ser243) p70S6K (Thr248)
p70S6K (Thr250) p70S6K (Thr252) p70S6K (Thr256) p70S6Kb (Ser219)
p70S6Kb (Ser356) p70S6Kb (Thr226) p70S6Kb (Thr228) p70S6Kb (Thr232)
p90RSK p90RSK (Ser221) p90RSK (Thr225) p90RSK (Tyr220)
PARP1 (Ser179) PCNA PCTAIRE1 (Tyr176) PCTAIRE2 (Tyr203)
PITSLRE (Tyr449) PITSLRE B (Tyr437) PMS2 (Ser425) POLA
POLD1 POLD2 PRC1 (Ser500) PRC1 (Ser501)
PRC1 (Ser513) PRC1 (Ser516) PRC1 (Thr509) PRC1 (Tyr511)
Profilin-1 Profilin-2 Rad17 RAD21
RAD21L1 RAD23A RAD23B RAD54B
RAD54B (Ser867) RAD54B (Ser869) Rb Rb (Ser773)
Rb (Ser780) Rb (Ser788) Rb (Ser794) Rb (Ser795)
Rb (Ser807) Rb (Ser811) Rb (Ser816) Rb (Thr774)
Rb (Thr778) Rb (Thr821) Rb (Thr823) Rb (Thr826)
Rb (Tyr790) Rb (Tyr805) Rb (Tyr813) RBBP4
RBBP7 RCC1 RFA2 RFC1 (Ser923)
RFC2 RFC3 RFC4 RFC5
RhoQ RPA1 RPA3 RRas
RSK2 RSK2 (Ser227) RSK2 (Thr231) RSK2 (Tyr226)
RSK3 RSK4 RSK4 (Ser232) RSK4 (Thr236)
RSK4 (Tyr231) Smad5 (Ser57) Smad5 (Ser58) Smc5
Smc5 (Ser792) Smc5 (Ser793) SMG1 (Ser111) SMG1 (Ser121)
SMG1L (Ser111) SMG1L (Ser121) tau (Ser713) tau (Ser717)
tau (Ser721) tau (Thr720) tau (Tyr711) TOP2A
TOP2B TOPBP1 XPG (Ser324) XPG (Ser697)
XPG (Ser699) XRCC1 XRCC1 (Ser241) ZNF828 (Ser405)
ZNF828 (Ser505) ZNF828 (Ser507) ZNF828 (Thr403)  
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