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PI3K / Akt 结合伴侣表

结合伴侣 结合作用 对 Akt 活性的影响 参考文献
GAPDH 结合活性 Akt 并限制其去磷酸化 阳性 Jacquin, M.A. et al. (2013) Cell Death Differ. 20, 1043–1054.
Jade-1 结合并抑制 Akt 激酶活性 阴性 Zeng, L. et al. (2013) Cancer Res. 73, 5371–5380.
Mst1 结合并抑制 Akt 激酶活性 阴性 Cinar, B. et al. (2007) EMBO J. 26, 4523–4534.
Jang, S.W. et al. (2007) J. Biol. Chem. 282, 30836–30844.
ArgBP2γ 结合 Akt 和 PAK1，并作为它们的接头蛋白 N/A Yuan, Z.Q. et al. (2005) J. Biol. Chem. 280, 21483–21490.
CBP Akt 结合并磷酸化 CBP，以调控 CBP 活性 N/A Liu, Y. et al. (2013) FEBS Lett. 587, 847–853.
PP1 结合 Akt 并去磷酸化 Akt Thr450 阴性 Xiao, L. et al. (2010) Cell Death Differ. 17, 1448–1462.
PLCγ1 Akt 结合并磷酸化 PLCγ1 N/A Wang, Y. et al. (2006) Mol. Biol. Cell 17, 2267–2277.
Skp2 Akt 结合并磷酸化 Skp2，以调控 Skp2 活性 N/A Lin, H. et al. (2009) Nat. Cell Biol. 11, 420–432.
Gao, D. et al. (2009) Nat. Cell Biol. 11, 397–408
PEA-15 Akt 结合并磷酸化 PEA-15，以调控其抗凋亡功能。 N/A Trencia, A. et al. (2003) Cell. Biol. 23, 4511–4521.
PHF20 Akt 结合并磷酸化 PHF20，以调控其亚细胞定位 N/A Park, S. et al. (2012) J. Biol. Chem. 287, 11151–11163.
PHLPP PHLPP 结合 Akt 并去磷酸化 Akt Ser473 阴性 Gao, T. et al. Mol. Cell 18, 13–24.
FKBP5 结合 Akt 并作为 Akt 与 PHLPP 相互作用的支架 阴性 Pei, H. et al. (2009) Cancer Cell 16, 259–266.
CKIP-1 结合 Akt 并抑制 Akt 磷酸化 阴性 Tokuda, E. et al. (2007) Cancer Res. 67, 9666–9676.
Ras 与 Akt 的普列克底物蛋白同源结构域相互作用 阳性 Yue, Y. et al. (2004) J. Biol. Chem. 279, 12883–12889.
BTBD10 结合 Akt 并抑制其去磷酸化 阳性 Nawa, M. et al. (2008) Cell Signal. 20, 493–505.
KCTD20 结合 Akt 并抑制其去磷酸化 阳性 Nawa, M. et al. (2013) BMC Biochem. 14, 27.
PAR-4 Akt 结合并磷酸化 PAR-4，以抑制其促凋亡活性 N/A Goswami, A. et al. (2005) Mol. Cell 20, 33–44.
Tpl2 Akt 结合并磷酸化 Tpl2 N/A Kane, L.P. et al. (2002) Mol. Cell. Biol. 22, 5962–5974.
SirT2 SirT2 与 Akt 相互作用，并且是最佳 Akt 激活所必需的 阳性 Ramakrishnan, G. et al. (2014) J. Biol. Chem. 289, 6054–6066.
NPM 结合 Akt 的普列克底物蛋白同源结构域，以促进细胞存活 N/A Lee, S.B. et al. (2008) Proc. Natl. Acad. Sci. USA 105, 16584–16589.
Kwon, I.S. et al. (2010) BMB Rep. 43, 127–132.
eEF1A 与 Akt 相互作用并导致 Akt 磷酸化 阳性 Pecorari, L. et al. (2009) Mol. Cancer 8, 58.
CLIPR-59 与 Akt 的激酶结构域相互作用，并调控 Akt 的亚细胞定位 N/A Ding, J. et al. (2009) Mol. Cell. Biol. 29, 1459–1471.
CNK1 结合并增强 Akt 激活 阳性 Fritz, R.D. et al. (2010) Oncogene 29, 3575–3582.
Phafin2 在溶酶体中结合 Akt 以调控自噬 N/A Matsuda–Lennikov, M. et al. (2014) PLoS One 9, e79795.
Btk 结合 Akt 并促进 Akt 磷酸化 阳性 Lindvall, J. et al. (2002) Biochem. Biophys. Res. Commun. 293, 1319–1326.
β-Parvin 结合 Akt 并阻止 Akt 与 ILK 相互作用 阴性 Kimura, M. et al. (2010) J. Cell Sci. 123, 747–755.
NS1 与 Akt 的普列克底物蛋白同源结构域相互作用 阳性 Matsuda, M. et al. (2010) Biochem. Biophys. Res. Commun. 395, 312–317.
α-Synuclein 结合 Akt 并促进 Akt 激活 阳性 Chung, J.Y. et al. (2011) Neurosignals 19, 86–96.
RACK1 RACK1 在含 PP2A 的复合体中与 Akt 相互作用 阴性 Li, G. et al. (2012) Nat. Commun. 3, 667.
ProF 结合 Akt 并影响 Akt 的亚细胞定位 N/A Fritzius, T. et al. (2006) Biochem. J. 399, 9–20.
p27 Kip1 Akt 结合并磷酸化 p27 N/A Liang, J. et al. (2002) Nat. Med. 8, 1153–1160.
Shin, I. et al. (2002) Nat. Med. 8, 1145–1152.
FoxA2/HNF3β Akt 结合并磷酸化 FoxA2/HNF3β N/A Wolfrum, C. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 11624–11629.
DNMT1 Akt 结合并磷酸化 DNMT1 N/A Estève, P.O. et al. (2011) Nat. Struct. Mol. Biol. 18, 42–48.

CST 非常感谢安大略省多伦多约克大学的 Michael Scheid 教授绘制此表。

参考文献

  1. Ding, Z. et al. (2006) A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc. Natl. Acad. Sci. U.S.A. 103, 15014–15019.
  2. Lin, H.K. et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 21, 4037–4048.
  3. Anai, M. et al. (2005) A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J. Biol. Chem. 280, 18525–18535.
  4. Mitsuuchi, Y. et al. (1999) Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18, 4891–4898.
  5. Zhang, P. et al. (2005) Regulated association of protein kinase B/Akt with breast tumor kinase. J. Biol. Chem. 280, 1982–1991.
  6. Fuhrmann, G. et al. (2001) Cdc25A phosphatase suppresses apoptosis induced by serum deprivation. Oncogene 20, 4542–4553.
  7. Miyata, Y. et al. (2004) CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol. Cell. Biol. 24, 4065–4074.
  8. Maira, S.M. et al. (2001) Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science 294, 374–380.
  9. Bauer, P.M. et al. (2003) Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J. Biol. Chem. 278, 14841–14849.
  10. Remy, I. et al. (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24, 1493–1504.
  11. Jahn, T. et al. (2002) Role for the adaptor protein Grb10 in the activation of Akt. Mol. Cell. Biol. 22, 979–991.
  12. Rane, M.J. et al. (2003) Heat shock protein 27 controls apoptosis by regulating Akt activation. J. Biol. Chem. 278, 27828–27835.
  13. Persad, S. et al. (2001) Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J. Biol. Chem. 276, 27462–27469.
  14. Cenni, V. et al. (2003) Interleukin-1-receptor-associated kinase 2 (IRAK2)-mediated interleukin-1-dependent nuclear factor kappaB transactivation in Saos2 cells requires the Akt/protein kinase B kinase. Biochem. J. 376, 303–311.
  15. Kim, A.H. et al. (2002) Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35, 697–709.
  16. Héron-Milhavet, L. et al. (2006) Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol. Cell. Biol. 26, 8267–8280.
  17. van den Heuvel, A.P. et al. (2002) Binding of protein kinase B to the plakin family member periplakin. J. Cell. Sci. 115, 3957–3966.
  18. Ahn, J.Y. et al. (2004) PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. J. Biol. Chem. 279, 16441–16451.
  19. Pim, D. et al. (2005) Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A. Oncogene 24, 7830–7838.
  20. Figueroa, C. et al. (2003) Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. J. Biol. Chem. 278, 47922–47927.
  21. Sun, L. et al. (2004) Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation. J. Cell. Sci. 117, 3021–3029.
  22. Reusch, H.P. et al. (2001) Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J. Biol. Chem. 276, 33630–33637.
  23. Conery, A.R. et al. (2004) Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. Nat. Cell Biol. 6, 366–372.
  24. Remy, I. et al. (2004) PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nat. Cell Biol. 6, 358–365.
  25. Laine, J. et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6, 395–407.
  26. Pekarsky, Y. et al. (2000) Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc. Natl. Acad. Sci. U.S.A. 97, 3028–3033.
  27. Du, K. et al. (2003) TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300, 1574–1577.

创建于 2007 年 9 月

修订时间 2014 年 9 月

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