Cell Signaling Technology

PTMScan®针对多通路服务

多途径的样本数据

PTMScan®针对多途径服务,执行有针对性的筛选和对药物发现,生物标志物发现,诊断研发非常关键的蛋白位点和信号节点蛋白定量分析。直接的PTMScan®针对多途径服务覆盖多个通路,包括Akt和MAPK,NF-κB和JAK / STAT信号通路。下表列出了PTMScan®针对多途径服务可以检测的蛋白位点。
 

综上所述, PTMScan®针对多途径服务提供了一个强大的方法定性鉴定和定量分析56种蛋白的111种独特磷酸化位点。

 

 蛋白位点按照主要蛋白质的字母顺序排列:

PTMScan®针对多通路服务的蛋白位点

 
PTMScan® Direct Multi-Pathway Protein Sites  
4EBP-2 (Thr37) 4EBP-2 (Thr46) β-Actin* Akt1 (Ser473)
Akt1 (Thr308) Akt1 (Thr312) Akt1 (Thr479) Akt2 (Ser474)
Akt2 (Ser478) Akt2 (Thr309) Anillin (Thr364) ATF-2 (Thr62)
ATF-2 (Thr69) ATF-2 (Thr71) Aurora A (Thr288) Aurora B (Thr232)
Aurora C (Thr198) Bad (Ser75) Caveolin-2 (Ser18) Caveolin-2 (Ser20)
cdc2 (Tyr15) cdc25C (Ser168) cdc25C (Ser216) CDK1 (Tyr15)
CDK5 (Tyr15) Chk1 (Ser345) Claudin-4 (Tyr208) CREB (Ser133)
DOT1L (Ser741) DOT1L (Thr751) FGFR4 (Tyr642) FGFR4 (Tyr643)
GADPH* GSK-3α (Ser21) GSK-3β (S9) Histone H3*
hnRNP LL (Ser61) IκBα (Ser32) IκBα (Ser36) IκBα (Tyr42)
c-Jun (Ser73) JunD (Ser100) JunD (Ser100) JunD (Ser90)
LMO7 (Ser318) LMO7 (Ser322) LMO7 (Tyr323) LRP6 (Ser1490)
MDM2 (Ser166) MEK1 (Ser217) MEK1 (Ser221) MEK2 (Ser222)
MEK2 (Ser226) MKP-2 (Ser386) mTOR (Ser2448) OSR1 (Thr185)
p42 MAPK (Thr184) p42 MAPK (Tyr186) p44 MAPK (Thr202) p44 MAPK (Tyr204)
p70 S6 Kinase (Thr252) p70 S6 Kinase (Thr412) p70 S6 Kinase β (Thr228) p85A (Tyr467)
p90RSK (Ser363) p90RSK (Thr359) PCH3 (Ser616) PCH3 (Thr609)
PDGFRα (Tyr849) PDK1 (Ser241) PI3 Kinase p55 (Tyr199) PI3 Kinase p85α (Tyr467)
PI3 Kinase p85β (Tyr464) PKCA (Thr496) PKN1 (Ser916) PRAS40 (Thr246)
Pyk2 (Tyr579) Pyk2 (Tyr580) B-Raf (Ser446) c-Raf (Ser338)
Rb (Ser780) Rb (Ser788) Rb (Ser795) Rictor (Ser1370)
Rictor (Ser1373) Rictor (Thr1376) RIP2 (Ser176) RSK2 (Ser227)
RSK4 (Ser389) S6 (Ser235) S6 (Ser236) S6 (Ser240)
S6 (Ser244) SAPK/JNK1 (Thr183) SAPK/JNK1 (Tyr185) JNK3 (Thr221)
JNK3 (Thr223) Smad1 (Ser463) Smad1 (Ser465) Stat3 (Ser701)
Stat3 (Ser727) Stat3 (Tyr705) Stat5 (Tyr694) Stat6 (Tyr641)
TBC1D1 (Ser237) Timeless (Ser1149) α-Tubulin* Wee1 (Ser642)
ZNF598 (Ser288) ZNF828 (Ser405) Zyxin (Tyr172)  

* 以下目标作为总蛋白参照标志物:β-肌动蛋白,组蛋白H3,GAPDH,和α-微管蛋白。

PTMScan®针对多途径服务样本数据

案例研究数据示例

注:下面的特定例研究已以Excel(XLS)格式保存。

样品PowerPoint报告摘要

PTMScan Sample Report Icon

样品PowerPoint总结报告  0.7 MB

 

 

PTMScan® 服务简介 

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PTMScan® 针对性服务