Cell Signaling Technology

PTMScan®细胞周期及DNA损伤服务

细胞周期及DNA损伤样本数据

PTMScan®针对细胞周期和DNA损伤服务提供方法,执行有针对性的筛选和对药物发现,生物标志物的发现,诊断研发非常关键的、与DNA损伤和细胞周期调控相关的蛋白位点和信号节点蛋白定量分析。下表列出了PTMScan®针对细胞周期和DNA损伤服务可以检测的蛋白位点。

总之,  PTMScan®针对细胞周期和DNA损伤服务提供了一个强大的方法定性鉴定和定量分析263种蛋白的168种独特磷酸化位点。

PTMScan Direct Cell Cycle & DNA Damage Pathway Coverage.

蛋白位点按照主要蛋白质网站字母顺序排列。

细胞周期 & DNA 损伤 蛋白位点  
Cell Cycle & DNA Damage Protein Sites  
53BP1 53BP1 (Ser265) α-tubulin APE1
ATM ATM (Ser1981) ATM (Ser1983) ATR
ATR (Ser428) ATRIP AurA (Thr287) AurA (Thr288)
AurA (Thr292) AurB AurB (Thr232) AurB (Thr236)
AurB (Tyr239) AurC (Thr198) AurC (Thr202) AurC (Tyr205)
β-Actin BLM BLM (Ser74) BRCA2 (Thr77)
Bub3 Bub3 (Ser135) Bub3 (Thr133) CBP
CCND1 (Thr286) CCND1 (Thr288) CCNE1 CCNK iso3
CCNL1 (Ser372) CCNL1 (Ser374) CCNL1 (Tyr376) CCNT1 (Ser626)
CCNYL1 CDC123 Cdc16 Cdc23
Cdc25B Cdc25C Cdc25C (Ser191) Cdc25C (Ser198)
Cdc27 Cdc37 Cdc42 CDC45L
CDCA7 (Thr213) CDK1 CDK1 (Thr14) CDK1 (Tyr15)
CDK1 (Tyr19) CDK10 CDK11 CDK2
CDK2 (Thr14) CDK2 (Tyr15) CDK3 CDK3 (Thr14)
CDK3 (Tyr15) CDK4 CDK5 (Tyr15) CDK6
CDK7 CDK8 CHED (Ser1054) CHED (Ser1065)
CHED (Ser1066) CHED (Thr1056) CHED (Thr1058) Chk1
Chk1 (Ser296) Chk1 (Ser307) Chk1 (Ser308) Chk1 (Ser315)
Chk1 (Ser316) Chk1 (Ser317) Chk1 (Ser345) Chk1 (Ser357)
Chk1 (Thr348) Chk1 (Tyr314) Chk2 Chk2 (Ser379)
DDB1 DNA-PK DNA-PK (Ser3205) ERK1
ERK1 (Thr202) ERK1 (Tyr204) ERK2 ERK2 (Thr185)
ERK2 (Tyr187) ERK5 (Thr219) ERK5 (Tyr221) FANCB
FANCD2 FANCI GAPDH H2AX
H2AX (Ser140) H2AX (Thr137) H3 JNK1 (Thr183)
JNK1 (Tyr185) JNK2 (Thr183) JNK2 (Thr188) JNK2 (Tyr185)
JNK3 (Thr221) JNK3 (Tyr223) Ku70 Ku80
LOC651610 LOC731751 (Ser3204) MCM2 MCM3
MCM4 MCM5 MCM6 MCM7
MKK3 (Ser253) MKK4 (Ser257) MLH1 MRE11A
MSH2 (Ser717) MSH6 (Ser309) MST1 (Ser40) MST1 (Ser43)
Myt1 (Ser40) NBS1 NPM1 (Ser125) NUCKS
NUCKS (Ser14) NUCKS (Ser181) NUCKS (Ser19) NuMA-1
NuMA-1 (Ser1772) NuMA-1 (Ser395) NuMA-1 (Thr1776) p300
p21Cip1 p21Cip1 (Ser130) p27Kip1 p27Kip1 (Ser175)
p27Kip1 (Ser178) p27Kip1 (Ser183) p27Kip1 (Thr170) p27Kip1 (Thr187)
p38α (Ser61) p38α (Thr175) p38α (Thr180) p38α (Tyr182)
p38δ (Thr180) p38δ (Tyr182) p38γ (Ser180) p38γ (Thr183)
p38γ (Tyr185) p53 (Ser392) p70S6K (Ser243) p70S6K (Thr248)
p70S6K (Thr250) p70S6K (Thr252) p70S6K (Thr256) p70S6Kb (Ser219)
p70S6Kb (Ser356) p70S6Kb (Thr226) p70S6Kb (Thr228) p70S6Kb (Thr232)
p90RSK p90RSK (Ser221) p90RSK (Thr225) p90RSK (Tyr220)
PARP1 (Ser179) PCNA PCTAIRE1 (Tyr176) PCTAIRE2 (Tyr203)
PITSLRE (Tyr449) PITSLRE B (Tyr437) PMS2 (Ser425) POLA
POLD1 POLD2 PRC1 (Ser500) PRC1 (Ser501)
PRC1 (Ser513) PRC1 (Ser516) PRC1 (Thr509) PRC1 (Tyr511)
Profilin-1 Profilin-2 Rad17 RAD21
RAD21L1 RAD23A RAD23B RAD54B
RAD54B (Ser867) RAD54B (Ser869) Rb Rb (Ser773)
Rb (Ser780) Rb (Ser788) Rb (Ser794) Rb (Ser795)
Rb (Ser807) Rb (Ser811) Rb (Ser816) Rb (Thr774)
Rb (Thr778) Rb (Thr821) Rb (Thr823) Rb (Thr826)
Rb (Tyr790) Rb (Tyr805) Rb (Tyr813) RBBP4
RBBP7 RCC1 RFA2 RFC1 (Ser923)
RFC2 RFC3 RFC4 RFC5
RhoQ RPA1 RPA3 RRas
RSK2 RSK2 (Ser227) RSK2 (Thr231) RSK2 (Tyr226)
RSK3 RSK4 RSK4 (Ser232) RSK4 (Thr236)
RSK4 (Tyr231) Smad5 (Ser57) Smad5 (Ser58) Smc5
Smc5 (Ser792) Smc5 (Ser793) SMG1 (Ser111) SMG1 (Ser121)
SMG1L (Ser111) SMG1L (Ser121) tau (Ser713) tau (Ser717)
tau (Ser721) tau (Thr720) tau (Tyr711) TOP2A
TOP2B TOPBP1 XPG (Ser324) XPG (Ser697)
XPG (Ser699) XRCC1 XRCC1 (Ser241) ZNF828 (Ser405)
ZNF828 (Ser505) ZNF828 (Ser507) ZNF828 (Thr403)  

PTMScan®针对细胞周期和DNA损伤服务示范案例研究数据

PTMScan® 服务简介 

PTMScan® 开发服务 

PTMScan® 针对性服务