Cell Signaling Technology

Jak/Stat 使用表

以下Jak/Stat使用表列示了在细胞因子和生长因子信号通路中酪氨酸激酶和Stat蛋白的各种组合。

配体 受体 Jak激酶 其他酪氨酸激酶 Stat家族成员
IL-6 IL-6Ra+gp130 Jak1,2, Tyk2 Hck Stat1, Stat3
IL-11 IL-11R+gp130 Jak1,2, Tyk2 Src, Yes Stat3
CNTF, CT-1, LIF, OSM CNTFR+gp130, CT-1R+gp130, LIFR+gp130, OSMR+gp130 Jak1,2, Tyk2 Src family Predominant: Stat3
Secondary: Stat1,5
G-CSF G-CSFR Jak2, Tyk2 Lyn Stat3
IL-12 (p40+p35) IL-12Rβ1+IL-12Rβ2 Jak2, Tyk2 Lck Stat4
Leptin LeptinR Jak2 not determined Stat3,5,6
IL-3 IL-3Rα+βc Jak2 Fyn, Hck, Lyn Stat3,5,6
IL-5 IL-5R+βc Jak2 Btk Stat3,5,6
GM-CSF GM-CSFR+βc Jak2 Hck, Lyn Stat3,5
Angiotensin GPCR Jak2, Tyk2 Stat1,2,3
Serotonin GPCR Jak2 Stat3
α-Thrombin GPCR Jak2 Stat1,3
Chemokines CXCR4 Jak2,3
IL-2 IL-2Rα+IL-2Rb+γc Jak1,2,3 Fyn, Hck, Lck, Syk, Tec Stat3,5
IL-4 IL-4Rα+γcR or IL-4Rα+IL-13Rα1 Jak1,3 Lck, Tec Stat6
IL-7 IL-7R+γc Jak1,3 Lyn Stat3,5
IL-9 IL-9R+γc Jak1,3 not determined Stat1,3,5
IL-13 IL-13Rα1+ IL-4Rα Jak1,2, Tyk2 Ctk Stat6
IL-15 IL-15Rα+IL-2Rβ+γc Jak1,3 Lck Stat3,5
IL-19 IL-20Rα+IL-20Rβ Jak1, ? Stat3
IL-20 IL-20Rα+IL-20Rβ, IL-22R+IL-20Rβ Jak1, ? Stat3
IL-21 IL-21R+γc Jak1,3 Stat1,3,5
IL-22 IL-22R+IL-10Rβ Jak1, Tyk2 Stat1,3,5
IL-23 (p40+p19) IL-12Rβ1+IL-23R Jak2 Tyk2 Stat4
IL-24 same as IL-20 Jak1, ? Stat3
IL-26 IL-20Rα+IL-10Rβ Jak1, Tyk2 Stat3
IL-27 (EBI3+p28) gp130+WSX1 Jak1,2, Tyk2 Stat1,2,3,4,5
IL-28A, IL-28B, IL-29 IL-28R+IL-10Rβ Jak1, Tyk2 Stat1,2,3,4,5
IL-31 IL-31Rα+OSMR Jak1,2, Tyk2 Stat1,3,5
IL-35 (p35+EBI3) gp130+WSX1 Jak1,2, Tyk2 Stat1,3,5
GH GHR Jak2 Src family Stat3,5 (mainly Stat5a)
Tpo TpoR (c-Mpl) Jak2, Tyk2 Lyn Stat1,3,5
Epo, Pro EpoR, ProlactinR Jak2 Src Family Stat5 (mainly Stat5a)
Interferon (IFNα/β) IFNAR1+IFNAR2 Jak1, Tyk2 Lck Predominant: Stat1,2
Secondary: Stat3,4,5,6
IFN-γ IFN-gR1+IFN-γR2 Jak1, Jak2 Hck, Lyn Stat1
IL-10 IL-10Rα+ IL-10Rβ Jak1, Tyk2 not determined Stat1,3,5
TLSP TLSPR and IL-7R Jak1, possibly Jak2 not determined Stat3,5
EGF EGFR Jak1 EGFR, Src Stat1,3,5
PDGF PDGFR Jak1,2 PDGFR, Src Stat1,3,5

感谢比利时布鲁塞尔Ludwig 癌症研究所的Stefan N. Constantinescu教授对这个表格的贡献。

created October 2008

revised April 2013

References