Cell Signaling Technology

Translational Control: Overview

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Translational Control: Overview

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通路描述:

新蛋白的合成是一个受到严密调控的过程,因此,允许转录后对各种刺激作出快速的响应。当核糖体分解成40S和60S两个亚基后,新蛋白的合成才能开始。真核翻译起始因子(eIF)催化形成有功能的核糖体,这包括40S亚基,mRNA和tRNA的结合,还有在第一个肽键形成后60S亚基的结合。大多数的刺激,如生长因子或压力,通过促进或抑制特定的eIF来调节翻译起始过程中的限速步骤。细胞内钙离子和cAMP水平的升高可以减弱翻译,这是通过阻滞真核延伸因子2(eEF2)实现的。

主要文献:

We would like to thank Carson Thoreen and David Sabatini, Whitehead Institute for Biomedical Research, MIT, Cambridge, MA, for reviewing this diagram.

created January 2002

revised November 2012

References