Cell Signaling Technology

SAPK/JNK Signaling Cascades

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SAPK/JNK Signaling Cascades

highlighted node

通路描述:

压力激活的蛋白激酶(Stress-activated protein kinase, SAPK)或称Jun氨基端激酶(Jun amino-terminal kinase,JNK) 是MAPK的家族成员,能被一系列的环境压力,炎症细胞因子,生长因子和GPCR激动剂所激活。压力信号通过Rho家族的小GTP 酶(small GTPase)向这条级联通路传导,这些小GTP酶包括(Rac,Rho,cdc42) 。和其他的MAPK情况一样,靠近膜的激酶是一个MAPKKK,一般是MEKK1-4 ,或者是一个混合激酶去磷酸化并激活MKK4(SEK)或MKK7,它们是 SAPK/JNK的激酶。另外,MKK4/7也可以被生发中心激酶(germinal center kinase,GCK)以一种GTPase 依赖的方式激活。活化后的SAPK/JNK转移到细胞核内调节多种转录因子。

主要文献:

We would like to thank Prof. John Blenis, Harvard Medical School, Boston, MA, for reviewing this diagram.

created January 2002

revised October 2012

References