Cell Signaling Technology

Signaling Pathways Activating p38 MAPK

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Signaling Pathways Activating p38 MAPK

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通路描述:

p38MAPK(α,β,γ和δ)是MAPK的家族成员,它们被一些环境压力和炎症细胞因子激活。和其他的MAPK级联结构一样,靠近细胞膜的成分是一个MAPKKK,一般是一个MEKK或者是一个混合激酶MLK (Mixed lineage kinase )。这个MAPKKK磷酸化并激活MKK3/6,这是p38MAPK 的激酶。当细胞受到凋亡刺激时,MKK3/6还可以被ASK1 激活。p38MAPK 调节的下游分子包括HSP27,MK2(MAPKAPK-2),MK3(MAPKAPK-3)和一些转录因子包括ATF-2,Stat-1,Max/Myc复合体,MEF-2,Elk-1 ,它还可以通过活化MSK1间接调节CREB分子。

主要文献:

We would like to thank Prof. John Blenis, Harvard Medical School, Boston, MA, for contributing to this diagram.

created January 2003

revised October 2012

References