Cell Signaling Technology

精于心,准于行,肿瘤免疫监控点IHC组合套装大促

于心,于行,无虚发一击必中

 

 

近年来,肿瘤免疫备受关注。T 细胞的免疫应答不仅受 TCR 的调控,还受辅助调节信号的精细调控。PD-L1、PD-L2、B7-H3、B7-H4 等免疫监控点蛋白是产生抑制的主要原因,它们抑制 T 细胞的活化。 此外 VISTA、LAG-3 和 TIM-3 等也产生抑制效应。与之相反,ICOS、CD40L 及 OX40 等可正向调节 T 细胞活化。有研究发现,加入这些蛋白的激动剂,可以提高 T 细胞对肿瘤的免疫。还有研究表明,与负调控因子的阻断剂联合使用,能加强抑制肿瘤的效果。此外,参与免疫代谢的重要蛋白如 IDO,Arginase-1,CD73 也起到了非常重要的免疫调节作用。

 

 

研究发现,肿瘤微环境显著影响免疫抑制,肿瘤浸润性的淋巴细胞,如效应性 T 细胞(CD8+)和调节性 T 细胞(FoxP3+)的比例会影响免疫监控点阻断治疗的效果。因此,很多时候需要对这些相关靶标进行同时检测,多重免疫组化就是较为理想的方法。这一领域的研究方兴未艾,为治愈癌症打开了新的窗口。

 

 

 

 

 

 

 

CST 精准医学重磅产品之肿瘤免疫监控点(CheckPoint)IHC组合促销:

 


精于心,准于行,肿瘤免疫监控点IHC组合套装大促

No. Name Size List Price Purchase
No. Name Size List Price Purchase
13079S Immunohistochemistry Application Solutions Kit (Rabbit) 1.0 Kit ( 120 slides ) ¥4912.0
13160S NT5E/CD73 (D7F9A) Rabbit mAb 100.0 µl ( 10 western blots ) ¥3100.0
13684S PD-L1 (E1L3N®) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥7500.0
14058S B7-H3 (D9M2L) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥3580.0
14572S B7-H4 (D1M8I) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥3580.0
14746P SignalStain® Citrate Unmasking Solution (10X) 25.0 ml ¥324.0
14747P SignalStain® EDTA Unmasking Solution (10X) 25.0 ml ¥247.0
15094S CD40 Ligand (D5J9Y) Rabbit mAb 100.0 µl ( 10 western blots ) ¥3100.0
15372S LAG3 (D2G4O™) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥3580.0
45208S TIM-3 (D5D5R™) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥7500.0
64953S VISTA (D1L2G™) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥3580.0
64988S PD-L1 (D5V3B) Rabbit mAb (Mouse Specific; IHC Specific) 100.0 µl ( 200 sections ) ¥3480.0
65713T PD-L1, CD3ε, CD8α Multiplex IHC Antibody Panel 1.0 Kit ( 50 sections ) ¥6000.0
78701T PD-L1, FoxP3, CD8α Multiplex IHC Antibody Panel 1.0 Kit ( 50 sections ) ¥6000.0
8114P SignalStain® Boost IHC Detection Reagent (HRP, Rabbit) 1.0 ml ( 10 slides ) ¥503.0
8125P SignalStain® Boost IHC Detection Reagent (HRP, Mouse) 1.0 ml ( 10 slides ) ¥503.0
82723S PD-L2 (D7U8C™) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥7500.0
83882S TIM-3 (D3M9R) XP® Rabbit mAb (Mouse Specific) 100.0 µl ( 10 western blots ) ¥3580.0
86163S PD-1 (D4W2J) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥3580.0
86630S IDO (D5J4E™) Rabbit mAb 100.0 µl ( 10 western blots ) ¥3100.0
89601S ICOS (D1K2T™) Rabbit mAb (IHC Specific) 100.0 µl ( 200 sections ) ¥3100.0
93668S Arginase-1 (D4E3M™) XP® Rabbit mAb 100.0 µl ( 10 western blots ) ¥3580.0

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