Cat. # | Size | Price | Inventory |
---|---|---|---|
88084SF | 100 µg |
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | 15 |
Source/Isotype | Mouse IgG1 |
Product Information
Human
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human galectin-1 protein.
Galectins are a family of β-galactose binding proteins that are characterized by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and their carbohydrate-binding site (1,2). Members of the galectin family have been implicated in a variety of biological functions including cell adhesion (3), growth regulation (4), cytokine production (5), T cell apoptosis (6), and immune responses (7). Galectin-1/LGALS1 has been shown to be expressed in a wide range of tissues and cell types. The level and pattern of expression of galectin-1 have been shown to change during development (8). In addition to a role in developmental processes, galectin-1 has been shown to be involved in central immune tolerance and may function in tumorigenesis by modulating the immune response to the tumor (9,10). Research studies have shown that galectin-1 expression is increased in several human cancers, suggesting a correlation with metastatic potential (10).
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