Cell Signaling Technology

Product Pathways - Lymphocyte Signaling

FoxP3 (D2W8E™) Rabbit mAb (IHC Specific) #98377

forkhead box P3   Fox   FoxP3   Regulatory T Cells   Treg   Tregs  

No. Size Price
98377S 100 µl ( 200 sections ) ¥3,100.00 现货查询 购买询价
98377 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
IHC-P 1:200 Human, Endogenous 45 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: IHC-P=Immunohistochemistry (Paraffin),

Specificity / Sensitivity

FoxP3 (D2W8E) Rabbit mAb (IHC Specific) recognizes endogenous levels of total FoxP3 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human FoxP3.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human colon carcinoma using FoxP3 (D2W8E) Rabbit mAb (IHC Specific).

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded COS-7 cell pellets, untransfected (left) or transfected with human FoxP3 protein (right), using FoxP3 (D2W8E) Rabbit mAb (IHC Specific).

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human tonsil using FoxP3 (D2W8E) Rabbit mAb (IHC Specific).

Background

Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain (1). The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 - FoxP4, which are broadly expressed and play important roles in organ development, immune response and cancer pathogenesis (2-4). The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors (4,5).

FoxP3 is crucial for the development of T cells with regulatory properties (Treg) (6). Mutations in FoxP3 are associated with immune dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX) (7), while overexpression in mice causes severe immunodeficiency (8). Research studies have shown that FoxP3 functions as a tumor suppressor in several types of cancer (9-11).

  1. Myatt, S.S. and Lam, E.W. (2007) Nat Rev Cancer 7, 847-59.
  2. Shu, W. et al. (2001) J Biol Chem 276, 27488-97.
  3. Lu, M.M. et al. (2002) Gene Expr Patterns 2, 223-8.
  4. Koon, H.B. et al. (2007) Expert Opin Ther Targets 11, 955-65.
  5. Li, S. et al. (2004) Mol Cell Biol 24, 809-22.
  6. Ochs, H.D. et al. (2007) Immunol Res 38, 112-21.
  7. Bennett, C.L. et al. (2001) Nat Genet 27, 20-1.
  8. Kasprowicz, D.J. et al. (2003) J Immunol 171, 1216-23.
  9. Zuo, T. et al. (2007) Cell 129, 1275-86.
  10. Zuo, T. et al. (2007) J Clin Invest 117, 3765-73.
  11. Wang, L. et al. (2009) Cancer Cell 16, 336-46.

Application References

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!

Protocols

Companion Products


For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

SignalStain is a trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

用户评论 --- 共 0

该产品暂无评论!

我要参与评论 :

如要参与评论请先登录网站

还没有网站账户?去注册一下吧

Products

 

Applications