Cell Signaling Technology

Product Pathways - Cytoskeletal Signaling

RalB (D9K6M) Rabbit mAb #90879

No. Size Price
90879S 100 µl ( 10 western blots ) ¥3,250.00 现货查询 购买询价 防伪查询
90879 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 26 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

RalB (D9K6M) Rabbit mAb recognizes endogenous levels of total RalB protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu142 of human RalB protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using RalB (D9K6M) Rabbit mAb.


RalA and RalB are members of the Ras family of small GTPases and are highly homologous in protein sequence. The functions of RalA and RalB are distinct yet overlapping. By binding to various effector proteins, RalA and RalB serve as important GTP sensors for exocytosis and membrane trafficking (1-3). RalA is required for Ras-related tumorigenesis (4) and RalB is important for tumor survival (5). In addition to tumor formation, Ral proteins also play a role in cancer cell migration and metastatic tumor invasion (6,7).

  1. Li, G. et al. (2007) J Neurosci 27, 190-202.
  2. van Dam, E.M. and Robinson, P.J. (2006) Int J Biochem Cell Biol 38, 1841-7.
  3. Camonis, J.H. and White, M.A. (2005) Trends Cell Biol 15, 327-32.
  4. Lim, K.H. et al. (2005) Cancer Cell 7, 533-45.
  5. Chien, Y. et al. (2006) Cell 127, 157-70.
  6. Oxford, G. et al. (2005) Cancer Res 65, 7111-20.
  7. Lim, K.H. et al. (2006) Curr Biol 16, 2385-94.

Application References

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