Product Pathways - Metabolism
MMS19 (D5J8J) Rabbit mAb #90637
|90637S||100 µl ( 10 western blots )||￥3,250.00 现货查询||购买询价|
|90637||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
MMS19 (D5J8J) Rabbit mAb recognizes endogenous levels of total MMS19 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu892 of human MMS19 protein.
Western blot analysis of extracts from various cell lines using MMS19 (D5J8J) Rabbit mAb.
Iron-sulfur (Fe-S) clusters (ISC) are cofactors for many proteins that display a wide range of biological functions, such as DNA maintenance, transcription, translation, cellular metabolism, electron transport, and oxidative phosphorylation (1). While structurally simple, the synthesis and insertion of ISC into Fe-S proteins are complex processes that involve many different proteins. MMS19 (methyl-methanesulfonate sensitivity 19) is a key component of the cytosolic Fe-S protein assembly complex, acting as an adaptor for a subset of Fe-S proteins including XPD and FANCJ, therefore playing an important role in DNA repair and transcription (2-4). MMS19 may also function as a coactivator for the estrogen receptor (5). In addition it has been reported that MMS19 is in a complex that is localized to the mitotic spindle and is required for proper chromosome segregation during mitosis (6).
- Wang, J. and Pantopoulos, K. (2011) Biochem J 434, 365-81.
- Stehling, O. et al. (2012) Science 337, 195-9.
- Gari, K. et al. (2012) Science 337, 243-5.
- Vashisht, A.A. et al. (2015) J Biol Chem 290, 14218-25.
- Wu, X. et al. (2001) J Biol Chem 276, 23962-8.
- Ito, S. et al. (2010) Mol Cell 39, 632-40.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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