Cell Signaling Technology

Product Pathways - Metabolism

UCP2 (D1O5V) Rabbit mAb #89326

BMIQ4   Mitochondrial uncoupling protein 2   sc-6526   SLC25A8   Solute carrier family 25 member 8   UCP 2   UCP2   UCPH   uncoupling protein 2 (mitochondrial. proton carrier)  

No. Size Price
89326S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
89326 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat,Monkey, Endogenous 32 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

UCP2 (D1O5V) Rabbit mAb recognizes endogenous levels of total UCP2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly153 of human UCP2 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from adipocytes and various cell lines using UCP2 (D1O5V) Rabbit mAb.

Background

Uncoupling protein 2 (UCP2) is a mitochondrial inner membrane transport protein that is expressed in a wide range of tissues (1). UCP2 inhibits mitochondrial glucose oxidation and promotes glycolysis in human pluripotent stem cells (hPSCs) (2). During early differentiation of hPSCs, the expression of UCP2 is repressed, which results in reduced glycolysis (2). This demonstrates a role for UCP2 in the metabolic reprogramming during differentiation of hPSCs (2). Overexpression of UCP2 in cancer cells stimulates oxidative phosphorylation in mitochondria and inhibits cell proliferation (3).

  1. Mailloux, R.J. et al. (2011) J Biol Chem 286, 21865-75.
  2. Zhang, J. et al. (2011) EMBO J 30, 4860-73.
  3. Esteves, P. et al. (2014) Cancer Res 74, 3971-82.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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