Cell Signaling Technology

Product Pathways - Metabolism

FAM96B (D4V9Z) Rabbit mAb #86302

No. Size Price
86302S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
86302 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat, Endogenous 18 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

FAM96B (D4V9Z) Rabbit mAb recognizes endogenous levels of total FAM96B protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln21 of human FAM96B protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using FAM96B (D4V9Z) Rabbit mAb.

Background

Iron-sulfur (Fe-S) clusters (ISC) are cofactors for many proteins that display a wide range of biological functions, such as DNA maintenance, transcription, translation, cellular metabolism, electron transport, and oxidative phosphorylation (1). While structurally simple, the synthesis and insertion of ISC into Fe-S proteins are complex processes that involve many different proteins (2). FAM96B, also known as MIP18 (MSS19-interacting protein of 18kDa), is a component of the cytosolic Fe-S protein assembly complex (3,4). FAM96B is in a complex with MMS19 that is responsible for assembly of multiple nuclear Fe-S proteins involved in DNA metabolism (5).

  1. Wang, J. and Pantopoulos, K. (2011) Biochem J 434, 365-81.
  2. Netz, D.J. et al. (2014) Trends Cell Biol 24, 303-12.
  3. van Wietmarschen, N. et al. (2012) J Biol Chem 287, 43351-8.
  4. Stehling, O. et al. (2013) Cell Metab 18, 187-98.
  5. Gari, K. et al. (2012) Science 337, 243-5.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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