Product Pathways - Metabolism
PEX5 (D7V4D) Rabbit mAb #83020
|83020S||100 µl ( 10 western blots )||￥3,250.00 现货查询||购买询价|
|83020||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting,
Specificity / Sensitivity
PEX5 (D7V4D) Rabbit mAb recognizes endogenous levels of total PEX5 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe326 of human PEX5 protein.
Peroxin-5 (PEX5) is the shuttle receptor that delivers proteins to peroxisomes (1). In the cytosol, PEX5 binds to the peroxisomal targeting signal 1 (PTS1), a short peptide sequence present at the extreme C termini of newly synthesized peroxisomal matrix proteins. The PEX5-cargo complex interacts with the peroxisomal docking/translocation machinery on the peroxisomal membrane, where the cargo is released into the organelle matrix. During this process, PEX5 is monoubiquitinated at a conserved cysteine residue, and the ubiquitin-PEX5 conjugate is released from the organelle into the cytosol, where PEX5 is deubiquitinated and ready the next round of targeting (2,3).
- Williams, C.P. and Stanley, W.A. (2010) Int J Biochem Cell Biol 42, 1771-4.
- Thoms, S. and Erdmann, R. (2006) Biochim Biophys Acta 1763, 1620-8.
- Francisco, T. et al. (2014) Biochimie 98, 29-35.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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