Product Pathways - Cytoskeletal Signaling
RASAL2 (D6K9L) Rabbit mAb #82481
|82481S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|82481||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
RASAL2 (D6K9L) Rabbit mAb recognizes endogenous levels of total RASAL2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro69 of human RASAL2 protein.
Western blot analysis of extracts from HeLa and MDA-MB-231 cells using RASAL2 (D6K9L) Rabbit mAb.
Small GTPases act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. RASAL2 was initially identified as a GAP for the small GTPase, Ras, and later shown to interact with the Rho-GEF ECT2, and to regulate Rho activity in human astrocytoma cells (1).
Researchers have implicated RASAL2 as a suppressor of migration and metastasis in human cancer (2), and have shown that RASAL2 downregulation promotes epithelial-mesenchymal transition and metastasis in ovarian cancer (3) and lung cancer (4). Conversely, other research studies show that RASAL2 can be oncogenic in triple negative breast cancer through activation of Rac1 signaling (5).
- Weeks, A. et al. (2012) Am J Pathol 181, 662-74.
- McLaughlin, S.K. et al. (2013) Cancer Cell 24, 365-78.
- Huang, Y. et al. (2014) Oncotarget 5, 6734-45.
- Li, N. and Li, S. (2014) Biochem Biophys Res Commun 455, 358-62.
- Feng, M. et al. (2014) J Clin Invest 124, 5291-304.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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