Product Pathways - Screening Technologies
Phospho-Thr-Pro-Arg Motif [pTPR] MultiMab™ Rabbit mAb mix #8142
|8142S||100 µl ( 10 western blots )||￥3,900.00 现货查询||购买询价|
|8142||carrier free & custom formulation / quantity||email request|
|W||1:1000||All Species Expected,||Endogenous||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting,
Specificity / Sensitivity
Phospho-Thr-Pro-Arg Motif [pTPR] Rabbit mAb detects endogenous levels of proteins only when phosphorylated at the threonine within the TPR motif. This antibody does not cross-react with phospho-serine or phospho-threonine residues in a different context.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide library containing the phospho-TPR motif.
The MAPK and CDK families of serine/threonine protein kinases play important roles in proliferation and cell cycle control. These kinases phosphorylate threonine or serine residues that are followed by a proline residue (1-3). MAPK phosphorylates substrates with the consensus sequence PX(S/T)P and CDKs phosphorylate substrates containing the consensus sequence (S/T)PXR/K (4,5). Some signaling molecules can be regulated by phosphorylation at a specific threonine followed by an arginine or lysine at the +2 position. For example, conventional PKC isozymes phosphorylate substrates containing a serine or threonine with Arg or Lys at the -3, -2 and +2 positions (6,7).
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For Research Use Only. Not For Use In Diagnostic Procedures.
Use of Cell Signaling Technology (CST) Motif Antibodies within certain methods (e.g., U.S. Patents No. 7,198,896 and 7,300,753) may require a license from CST. For information regarding academic licensing terms please have your technology transfer office contact CST Legal Department at CST_ip@cellsignal.com. For information regarding commercial licensing terms please contact CST Pharma Services Department at firstname.lastname@example.org.
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