Product Pathways - Neuroscience
GRK3 (D8G6V) Rabbit mAb #80362
|80362S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|80362||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting,
Specificity / Sensitivity
GRK3 (D8G6V) Rabbit mAb recognizes endogenous levels of total GRK3 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys454 of human GRK3 protein.
Western blot analysis of extracts from mouse brain and various cell lines using GRK3 (D8G6V) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
G-protein-coupled receptor kinase 3 (GRK3), also known as beta-adrenergic receptor kinase 2 (beta-ARK2), is a member of the GRK family, which phosphorylates the activated form of G-protein-coupled receptors (GPCRs) and initiates the desensitization process of GPCR (1). GRK3 has been implicated in the phosphorylation of GPCRs, enabling their interaction with beta-arrestin, and facilitating their signaling through ERK1/2 phosphorylation (2). More recently, GRK3 was found to play a critical role in tumor progression through stimulation of angiogenesis; furthermore, GRK3 was found to be overexpressed in human prostate cancer, in particular in metastatic tumors (3).
- Pitcher, J.A. et al. (1998) Annu Rev Biochem 67, 653-92.
- Macey, T.A. et al. (2006) J Biol Chem 281, 34515-24.
- Li, W. et al. (2014) Proc Natl Acad Sci U S A 111, 1521-6.
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For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
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