Cell Signaling Technology

Product Pathways - Phosphatases

CTDSPL2 (D79G11) Rabbit mAb #6932

No. Size Price
6932S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
6932 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Rat,Monkey, Endogenous 62 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

CTDSPL2 (D79G11) Rabbit mAb recognizes endogenous levels of total CTDSPL2 protein.

CTDSPL2 (D79G11) Rabbit mAb兔单抗能够检测内源性CTDSPL2总蛋白水平。

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CTDSPL2 protein.


Western Blotting

Western Blotting

Western blot analysis of extracts from HeLa and Hep G2 cells using CTDSPL2 (D79G11) Rabbit mAb.

使用CTDSPL2 (D79G11) Rabbit mAb兔单抗,免疫印迹(Western blot)分析HeLa和HepG2细胞中CTDSPL2的蛋白水平。


CTD small phosphatase-like protein 2 (CTDSPL2, HSPC129) is a putative RNA-polymerase II carboxy-terminal domain (CTD) phosphatase (1) that belongs to a small subfamily of CTD phosphatases (2). The CTD of RNA polymerase II contains multiple Y-S-P-T-S-P-S repeats that are phosphorylated during the transcription cycle (3,4). In general, CTD phosphatases regulate the reversible CTD phosphorylation state of RNA-polymerase II at several stages of RNA synthesis and during post-transcriptional modification (4-6). CTDSPL2 has several structural and functional similarities to other CTD phosphatases, including FCP1, SCP1, DULLARD, and UBLCP1 (1,2).

CTD small phosphatase-like protein 2 (CTDSPL2, HSPC129)是一个假设RNA-polymerase II carboxy-terminal domain (CTD)磷酸酶(1),这属于CTD磷酸酶的一个小亚家族(2)。RNA polymerase II的CTD包含多重的Y-S-P-T-S-P-S重复序列,该序列是在转录循环期间被磷酸化(3,4)。一般而言,在RNA合成的数个步骤和在转录后修饰期间,CTD磷酸酶调节RNA-polymerase II的可逆CTD磷酸化作用(4-6)。CTDSPL2蛋白在数个结构性和功能性类似与其它CTD磷酸酶,包括FCP1、SCP1、DULLARD和UBLCP1 (1,2)。

  1. Qian, H. et al. (2007) Mol Cell Biochem 303, 183-8.
  2. Kim, Y. et al. (2007) Proc Natl Acad Sci USA 104, 6596-601.
  3. Corden, J.L. et al. (1985) Proc Natl Acad Sci USA 82, 7934-8.
  4. Ahn, S.H. et al. (2004) Mol Cell 13, 67-76.
  5. Dahmus, M.E. (1996) J Biol Chem 271, 19009-12.
  6. Goodrich, J.A. and Tjian, R. (1994) Cell 77, 145-56.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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