Cell Signaling Technology

Product Pathways - Neuroscience

Arg3.1 (D6H9N) Rabbit mAb #65650

sc-15325   sc-17839  

No. Size Price
65650S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
65650 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 51 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Homology

Species predicted to react based on 100% sequence homology: Mouse, Rat,

Specificity / Sensitivity

Arg3.1 (D6H9N) Rabbit mAb recognizes endogenous levels of total Arg3.1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val209 of human Arg3.1 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human Arg3.1 (hArg3.1-Myc/DDK; +), and extracts from SK-N-MC cells using Arg3.1 (D6H9N) Rabbit mAb.

Background

Arg3.1, also known as Arc for activity-regulated cytoskeleton-associated protein, is an immediate early gene whose expression is necessary for synaptic plasticity (1). Arg3.1 expression is induced by many experimental stimuli such as LTP (2), LTD (3), and learning. Arg3.1 is also involved in the regulation of synaptic strength and homeostatic scaling by promoting AMPA receptors endocytosis (5,6). Arg3.1 dysregulation has been proposed to participate in cognitive decline during aging (7).

  1. Guzowski, J.F. et al. (1999) Nat Neurosci 2, 1120-4.
  2. Lyford, G.L. et al. (1995) Neuron 14, 433-45.
  3. Guzowski, J.F. et al. (2000) J Neurosci 20, 3993-4001.
  4. Guzowski, J.F. et al. (2001) J Neurosci 21, 5089-98.
  5. Chowdhury, S. et al. (2006) Neuron 52, 445-59.
  6. Rial Verde, E.M. et al. (2006) Neuron 52, 461-74.
  7. Fletcher, B.R. et al. (2014) Neurobiol Learn Mem 115, 58-67.

Application References

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Protocols

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For Research Use Only. Not For Use In Diagnostic Procedures.

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