Cell Signaling Technology

Product Pathways - Adhesion

Integrin αV (D2N5H) Rabbit mAb #60896


No. Size Price
60896S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
60896 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat,Monkey, Endogenous 135, 140 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

Integrin αV (D2N5H) Rabbit mAb recognizes endogenous levels of total Integrin αV.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the central region of human integrin αV protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using Integrin αV (D2N5H) Rabbit mAb (upper) or α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower).


Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2).

Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on αV integrin as a key therapeutic target in the treatment of cancer (10-12).

  1. Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.
  2. Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
  3. Koistinen, P. et al. (2004) Int J Cancer 112, 61-70.
  4. Davidson, B. et al. (2003) Gynecol Oncol 90, 248-57.
  5. Schwartz, E.A. et al. (1999) Circ Res 84, 315-22.
  6. Suzuma, K. et al. (1998) Invest Ophthalmol Vis Sci 39, 1028-35.
  7. Eliceiri, B.P. and Cheresh, D.A. (1999) J Clin Invest 103, 1227-30.
  8. Friedlander, M. et al. (1995) Science 270, 1500-2.
  9. Perruzzi, C.A. et al. (2003) J Invest Dermatol 120, 1100-9.
  10. Strieth, S. et al. (2006) Int J Cancer 119, 423-31.
  11. Kumar, C.C. (2003) Curr Drug Targets 4, 123-31.
  12. Tucker, G.C. (2006) Curr Oncol Rep 8, 96-103.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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