Cell Signaling Technology

Product Pathways - Cytoskeletal Signaling

MARCKSL1 (D4I9P) Rabbit mAb #59568

No. Size Price
59568S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
59568 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse, Endogenous 40 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

MARCKSL1 (D4I9P) Rabbit mAb recognizes endogenous levels of total MARCKSL1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro186 of human MARCKSL1 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using MARCKSL1 (D4I9P) Rabbit mAb (upper) or β-actin (D6A8) Rabbit mAb #8457 (lower).

Background

Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS/ MARCKS-like protein 1/ MacMARCKS/ MLP/ MRP) is a widely expressed membrane-bound PKC substrate involved in multiple cellular functions (1). MARCKSL1 is a MARCKS homolog that also serves as a substrate for PKC, and regulates cytoskeletal dynamics, migration, adhesion, and proliferation.

In response to phosphorylation by JNK, MARCKSL1 regulates migration and actin dynamics in neuronal and prostate cancer cells (2). In the developing retina, MARCKSL1 regulates cell proliferation, and its expression decreases as retinal development progresses (3). Researchers have shown that MARCKSL1 may serve as a prognostic marker in lymph node-negative breast cancer (4).

  1. Ramsden, J.J. (2000) Int J Biochem Cell Biol 32, 475-9.
  2. Björkblom, B. et al. (2012) Mol Cell Biol 32, 3513-26.
  3. Zhao, J. et al. (2007) Biochem J 408, 51-9.
  4. Jonsdottir, K. et al. (2012) Breast Cancer Res Treat 135, 381-90.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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