Product Pathways - Chromatin Regulation / Epigenetics
TDRD3 (D3O2G) Rabbit mAb #5942
|5942S||100 µl ( 10 western blots )||￥3,250.00 现货查询||购买询价|
|5942||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
TDRD3 (D3O2G) Rabbit mAb recognizes endogenous levels of total TDRD3 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TDRD3 protein.
Western blot analysis of extracts from various cell lines using TDRD3 (D3O2G) Rabbit mAb.
Tudor domain-containing protein 3 (TDRD3) contains a tudor domain through which it binds to asymmetric di-methyl histone H3 (Arg17) and asymmetric di-methyl histone H4 (Arg3). Both of these histone marks are associated with transcription activation (1,2). TDRD3 is targeted to estrogen responsive genes where it performs as a coactivator (1). TDRD3 acts as a scaffolding protein to recruit Topoisomerase III B (TOP3B) to target genes to reduce transcription-generated R loops by relaxing negatively supercoiled DNA thereby reducing genomic instability (3). In addition to the nucleus, TDRD3 also resides in the cytoplasm where it associates with actively translating polyribosomes and accumulates into stress granules upon exposure to stress, implicating its role in post-transcriptional regulation of RNA (2,4).
- Yang, Y. et al. (2010) Mol Cell 40, 1016-23.
- Goulet, I. et al. (2008) Hum Mol Genet 17, 3055-74.
- Yang, Y. et al. (2014) Mol Cell 53, 484-97.
- Linder, B. et al. (2008) Hum Mol Genet 17, 3236-46.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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