Product Pathways - Growth Factors/Cytokines
TNFSF15 (D1C8W) Rabbit mAb #57221
|57221S||100 µl ( 10 western blots )||￥3,250.00 现货查询||购买询价|
|57221||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting,
Specificity / Sensitivity
TNFSF15 (D1C8W) Rabbit mAb recognizes endogenous levels of total human TNFS15 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu88 of human TNFSF15 protein.
TNFSF15 (TL1A), a member of the TNF superfamily of proteins, is a splice variant of the TL1/VEGI gene (1). Endothelial cells, monocytes, macrophages, and dendritic cells express TL1A, which is upregulated by proinflammatory cytokines, microorganisms, and AMPK activation (1-4). TL1A activates the NF-κB and JNK pathways through its receptor, DR3 (1,5). TL1A may function as a costimulatory signal for T cell activation, specifically regulating Th17 cell development and proliferation (1,2,6). Mouse models suggest a role for TL1A as a driver for the inflammation and pathogenesis associated with inflammatory bowel disease (7,8).
- Migone, T.S. et al. (2002) Immunity 16, 479-92.
- Jones, G.W. et al. (2011) FASEB J 25, 409-19.
- Zhou, J. et al. (2011) Oncogene 30, 1892-900.
- Shih, D.Q. et al. (2009) Eur J Immunol 39, 3239-50.
- Haridas, V. et al. (1999) Oncogene 18, 6496-504.
- Pappu, B.P. et al. (2008) J Exp Med 205, 1049-62.
- Meylan, F. et al. (2011) Mucosal Immunol 4, 172-85.
- Taraban, V.Y. et al. (2011) Mucosal Immunol 4, 186-96.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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