Cell Signaling Technology

Product Pathways - Growth Factors/Cytokines

TNFSF15 (D1C8W) Rabbit mAb #57221

No. Size Price
57221S 100 µl ( 10 western blots ) ¥3,250.00 现货查询 购买询价 防伪查询
57221 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 28 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

TNFSF15 (D1C8W) Rabbit mAb recognizes endogenous levels of total human TNFS15 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu88 of human TNFSF15 protein.

Western Blotting

Western Blotting

Western blot analysis of human umbilical vein endothelial cells, untreated (-) or treated with TNF-α #8902 (50 ng/ml, 24 hr; +), using TNFSF15 (D1C8W) Rabbit mAb (upper) and β-Actin (13E5) Rabbit mAb #4970 (lower).


TNFSF15 (TL1A), a member of the TNF superfamily of proteins, is a splice variant of the TL1/VEGI gene (1). Endothelial cells, monocytes, macrophages, and dendritic cells express TL1A, which is upregulated by proinflammatory cytokines, microorganisms, and AMPK activation (1-4). TL1A activates the NF-κB and JNK pathways through its receptor, DR3 (1,5). TL1A may function as a costimulatory signal for T cell activation, specifically regulating Th17 cell development and proliferation (1,2,6). Mouse models suggest a role for TL1A as a driver for the inflammation and pathogenesis associated with inflammatory bowel disease (7,8).

  1. Migone, T.S. et al. (2002) Immunity 16, 479-92.
  2. Jones, G.W. et al. (2011) FASEB J 25, 409-19.
  3. Zhou, J. et al. (2011) Oncogene 30, 1892-900.
  4. Shih, D.Q. et al. (2009) Eur J Immunol 39, 3239-50.
  5. Haridas, V. et al. (1999) Oncogene 18, 6496-504.
  6. Pappu, B.P. et al. (2008) J Exp Med 205, 1049-62.
  7. Meylan, F. et al. (2011) Mucosal Immunol 4, 172-85.
  8. Taraban, V.Y. et al. (2011) Mucosal Immunol 4, 186-96.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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