Cell Signaling Technology

Product Pathways - Metabolism

PRSS15/LONP1 (D7L8M) Rabbit mAb #56266

No. Size Price
56266S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
56266 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 106 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

PRSS15/LONP1 (D7L8M) Rabbit mAb recognizes endogenous levels of total PRSS15/LONP1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe920 of human PRSS15/LONP1 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from 293 and HeLa cells using PRSS15/LONP1 (D7L8M) Rabbit mAb.

Background

PRSS15/LONP1 is an ATP-dependent serine protease that selectively degrades misfolded, misassembled, or damaged proteins in mitochondrial matrix. PRSS15/LONP1 is induced by hypoxic, proteotoxic, and endoplasmic reticulum (ER) stress to support cell survival (1). It has been reported that PRSS15/LONP1 inducibility is decreased during aging and chronic stress (2-4). PRSS15/LONP1 is found to be substantially elevated in lymphoma cells compared to resting or activated B cells, and knock-down or inhibition of PRSS15/LONP1 induces apoptosis in lymphoma cells (5). Mutation in PRSS15/LONP1 is associated with CODAS syndrome, a multi-system developmental disorder characterized by cerebral, ocular, dental, auricular, and skeletal anomalies (6).

  1. Pinti, M. et al. (2015) Cell Mol Life Sci, 1-18.
  2. Bota, D.A. et al. (2002) FEBS Lett 532, 103-6.
  3. Lee, C.K. et al. (1999) Science 285, 1390-3.
  4. Ngo, J.K. et al. (2011) J Gerontol A Biol Sci Med Sci 66, 1178-85.
  5. Gibellini, L. et al. (2015) Oncotarget 6, 25466-83.
  6. Strauss, K.A. et al. (2015) Am J Hum Genet 96, 121-35.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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