Cell Signaling Technology

Product Pathways - Metabolism

IP6K3 (D9O7J) Rabbit mAb #54322

ATP:1D-myo-inositol-hexakisphosphate phosphotransferase   IHPK3   Inositol hexakisphosphate kinase 3   Inositol hexaphosphate kinase 3   InsP6 kinase 3   INSP6K3   IP6K3   MGC102928  

No. Size Price
54322S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
54322 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 46 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

IP6K3 (D9O7J) Rabbit mAb recognizes endogenous levels of total IP6K3 protein. This antibody does not cross-react with IP6K1 or IP6K2 proteins.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala140 of human IP6K3 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using IP6K3 (D9O7J) Rabbit mAb.

IP

IP

Immunoprecipitation of IP6K3 from HepG2 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is IP6K3 (D9O7J) Rabbit mAb. Western blot analysis was performed using IP6K3 (D9O7J) Rabbit mAb.

Background

Inositol hexakisphosphate kinase 3 (IP6K3) is a member of the inositol hexakisphosphate kinase family (1). These kinases are essential for producing inositol pyrophosphates (1). IP6K3 is highly expressed in the cerebellar Purkinje cells, interacts with adducin and spectrin, and plays an important role in determining the cytoskeletal organization and function of these cells (1). In addition, the expression of IP6K3 increases upon treatment with titanium dioxide nanoparticles suggesting a role for IP6K3 in the genotoxicity caused by these nanoparticles (2).

  1. Fu, C. et al. (2015) J Neurosci 35, 11056-67.
  2. El-Said, K.S. et al. (2014) J Nanobiotechnology 12, 48.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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