Product Pathways - Metabolism
FBP1 Antibody #52804
|52804S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|52804||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting,
Specificity / Sensitivity
FBP1 Antibody recognizes endogenous levels of total FBP1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human FBP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Fructose-1,6-bisphosphatase 1 (FBP1 or FBPase1), a rate limiting enzyme in gluconeogenesis, catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate (1). The inhibition of FBP1 expression in basal-like breast cancer (BLBC) cells leads to metabolic reprogramming including enhanced glycolysis, which leads to increased glucose uptake, biosynthesis of macromolecules, and activation of PKM2 (1). This metabolic reprogramming gives the cancer cells more cancer stem cell (CSC)-like properties and increases their tumorigenicity (1). Furthermore, the depletion of FBP1 was found in more than 600 clear cell renal cell carcinoma (ccRCC) tumors indicating that FBP1 inhibits ccRCC tumor progression (2).
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