Product Pathways - Angiogenesis
HGF β (D6S7D) XP® Rabbit mAb #52445
|52445S||100 µl ( 10 western blots )||￥3,580.00 现货查询||购买询价|
|52445T||20 µl ( 2 western blots )||￥1,400.00 现货查询||购买询价|
|52445||carrier free & custom formulation / quantity||email request|
|W||1:1000||Human,||Endogenous||35, 85||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IHC-P=Immunohistochemistry (Paraffin),
Specificity / Sensitivity
HGF β (D6S7D) XP® Rabbit mAb recognizes endogenous levels of total HGF protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human HGF protein.
Immunohistochemical analysis of paraffin-embedded human infiltrating ductal carcinoma of the breast HGF β (D6S7D)
XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human embryonal rhabdomyosarcoma using HGF β (D6S7D) XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human uterine rhabdomyosarcoma using HGF β (D6S7D) XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded A-204 (left) and HeLa (right) cell pellets using HGF β (D6S7D) XP® Rabbit mAb.
The Hepatocyte Growth Factor (HGF, also known as Scatter Factor) was initially discovered as a mitogenic cytokine that induced hepatocyte replication and proliferation (1-3). HGF is produced by stromal cells where it is processed by extracellular serine proteases into a heterodimer consisting of alpha and beta subunits (4). Through activation of its receptor, cMET, HGF has a wide range of effects beyond hepatocytes that includes angiogensis, epithelial cell proliferation and morphogenesis, and tissue protection and regeneration (5). The HGF-cMET axis has been associated with several diseases, including cancer, where HGF has been shown to promote invasion, metastasis, and drug resistance (6,7). These research studies suggest that HGF is a potential diagnostic and therapeutic target.
- Nakamura, T. et al. (1984) Biochem Biophys Res Commun 122, 1450-9.
- Russell, W.E. et al. (1984) J Cell Physiol 119, 183-92.
- Gohda, E. et al. (1988) J Clin Invest 81, 414-9.
- Kataoka, H. et al. Cancer Metastasis Rev 22, 223-36.
- Nakamura, T. and Mizuno, S. (2010) Proc Jpn Acad Ser B Phys Biol Sci 86, 588-610.
- Matsumoto, K. and Nakamura, T. (2006) Int J Cancer 119, 477-83.
- Yano, S. et al. (2008) Cancer Res 68, 9479-87.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
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For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
SignalStain is a trademark of Cell Signaling Technology, Inc.
Tween is a registered trademark of ICI Americas, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
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