Cell Signaling Technology

Product Pathways - Chromatin Regulation / Epigenetics

MEX3C (D5T2Z) Rabbit mAb #50844

No. Size Price
50844S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
50844 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat, Endogenous 80 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

MEX3C (D5T2Z) Rabbit mAb recognizes endogenous levels of total MEX3C protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala54 of human MEX3C protein.

Western Blotting

Western Blotting

Western blot analysis of extracts frm various cell lines using MEX3C (D5T2Z) Rabbit mAb.

Western Blotting

Western Blotting

Western blot analysis of extracts from 293T cells, mock transfected or transfected with full-length human MEX3C (hMEX3C), using MEX3C (D5T2Z) Rabbit mAb (upper) or GAPDH (D16H11) Rabbit mAb #5174 (lower).


MEX3C is an RNA-binding E3 ubiquitin ligase implicated in a diverse set of biological functions.

Along with PIGN and ZNF516, MEX3C has been identified as a suppressor of chromosome instability (CIN), which drives intratumor heterogeneity and has been associated with poor prognosis in colon cancer. Silencing of the Mex3c gene induces chromosome instability through replication stress/impaired replication fork progression (1).

In mice, absence of the Mex3c gene causes growth retardation and reduced insulin-like growth factor 1 (IGF1) expression (2). Researchers have shown that murine MEX3C plays a role in controlling energy expenditure, physical activity and degree of adiposity (3,4). In the immune system, MEX3C is involved in post-transcriptional regulation of HLA-A2 (5), and plays a role in eliciting antiviral response (6).

  1. Burrell, R.A. et al. (2013) Nature 494, 492-6.
  2. Jiao, Y. et al. (2012) Mol Biol Cell 23, 1404-13.
  3. Jiao, Y. et al. (2012) Mol Cell Biol 32, 4350-62.
  4. Han, C. et al. (2014) J Endocrinol 221, 457-68.
  5. Cano, F. et al. (2012) EMBO J 31, 3596-606.
  6. Kuniyoshi, K. et al. (2014) Proc Natl Acad Sci U S A 111, 5646-51.

Application References

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