Cell Signaling Technology

Product Pathways - Vesicle Trafficking

LAMP2 (D5C2P) Rabbit mAb #49067


No. Size Price
49067S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
49067 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 100-130 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

LAMP2 (D5C2P) Rabbit mAb recognizes endogenous levels of total LAMP2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human LAMP2 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using LAMP2 (D5C2P) Rabbit mAb.


Lysosome-associated membrane protein 1 and 2 (LAMP1 and LAMP2) are two abundant lysosomal membrane proteins (1,2). Both are transmembrane proteins and are heavily glycosylated at the amino-terminal luminal side of the lysosomal inner leaflet, which protects the proteins from proteolysis (3). The carboxy terminus of LAMP1 is exposed to the cytoplasm and contains a tyrosine sorting motif that targets LAMP to lysosomal membranes (4). LAMP1 and LAMP2 are 37% homologous in their protein sequences. Both LAMP1 and LAMP2 are involved in regulating lysosomal motility during lysosome-phagosome fusion and cholesterol trafficking (5,6).

  1. Eskelinen, E.L. et al. (2003) Trends Cell Biol 13, 137-45.
  2. Fukuda, M. (1991) J Biol Chem 266, 21327-30.
  3. Kundra, R. and Kornfeld, S. (1999) J Biol Chem 274, 31039-46.
  4. Rohrer, J. et al. (1996) J Cell Biol 132, 565-76.
  5. Huynh, K.K. et al. (2007) EMBO J 26, 313-24.
  6. Eskelinen, E.L. et al. (2004) Mol Biol Cell 15, 3132-45.

Application References

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