Product Pathways - Cytoskeletal Signaling
KLC1 (D2T2R) Rabbit mAb #48633
|48633S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|48633||carrier free & custom formulation / quantity||email request|
|W||1:1000||Human,||Endogenous||65, 75||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
KLC1 (D2T2R) Rabbit mAb recognizes endogenous levels of total KLC1 protein. This antibody also cross-reacts with an unidentified protein of 25 kDa.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly443 of human KLC1 protein.
Western blot analysis of extracts from various cell lines using KLC1 (D2T2R) Rabbit mAb.
Kinesins are heterotetrameric motor proteins that transport cargo along microtubule tracks toward their plus ends (anterograde direction) in an ATP-dependent manner. Two heavy chains contain the motor activity, while two kinesin light chains act as adaptor proteins that may be required for binding of specific cargo and/or regulation of heavy chain catalytic activity. The amino terminus of kinesin light chain 1 (KLC1) binds to kinesin heavy chains while the KLC1 carboxy-terminal tetratricopeptide repeat (TPR) domain binds cargo (1-3). Phosphorylation of KLC1 at Ser521 by AMPK may regulate insulin granule dynamics (4,5). Research studies identify a KLC1-ALK fusion protein in human lung adenocarcinoma, and this finding may provide insight for future therapeutics (6).
- Verhey, K.J. and Hammond, J.W. (2009) Nat Rev Mol Cell Biol 10, 765-77.
- Hirokawa, N. et al. (2009) Nat Rev Mol Cell Biol 10, 682-96.
- Kawano, T. et al. (2012) Traffic 13, 834-48.
- McDonald, A. et al. (2010) Biochem Soc Trans 38, 205-8.
- McDonald, A. et al. (2009) Islets 1, 198-209.
- Togashi, Y. et al. (2012) PLoS One 7, e31323.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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