Cell Signaling Technology

Product Pathways - Chromatin Regulation / Epigenetics

FBXL10 (D3T8J) Rabbit mAb #44570

CXXC2   FBL10   JHDM1B   KDM2B   NDY1   PCCX2  

No. Size Price
44570S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
44570 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Transfected Only 180 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

FBXL10 (D3T8J) Rabbit mAb recognizes transfected levels of total FBXL10 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the human FBXL10 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from 293T cells, untransfected (-) or transfected with human FBXL10 (hFBXL10; +), using FBXL10 (D3T8J) Rabbit mAb.


F-box and leucine-rich repeat protein 10 (FBXL10), also known as lysine-specific demethylase 2B (KDM2B) and JmjC domain-containing histone demethylation protein 1B (JHDM1B), is a lysine-specific histone demethylase protein that demethylates Lys4 and Lys36 of histone H3 (1,2). FBXL10 contains a zinc finger-CxxC5 DNA binding domain that binds to un-methylated CpG dinucleotides and has been shown to function as part of a non-canonical polycomb repressor complex (PRC1) that is associated with repression of developmentally regulated genes (3-5). In embryonic stem cells, FBXL10 is critical for targeting PRC1 to CpG islands and regulating gene expression during differentiation. In addition, FBXL10 is over-expressed in various cancers where it functions to induce cell proliferation and repress senescence through repression of the p15Ink4b gene locus (6-8). High expression of FBXL10 in pancreatic ductal adenocarcinoma is associated with metastasis, while high expression in acute myeloid leukemia is associated with increased proliferation and self-renewal of leukemic stem cells (6-8).

  1. He, J. et al. (2008) Nat Struct Mol Biol 15, 1169-75.
  2. Frescas, D. et al. (2007) Nature 450, 309-13.
  3. Boulard, M. et al. (2015) Nat Genet 47, 479-85.
  4. Wu, X. et al. (2013) Mol Cell 49, 1134-46.
  5. Farcas, A.M. et al. (2012) Elife 1, e00205.
  6. Tzatsos, A. et al. (2013) J Clin Invest 123, 727-39.
  7. Nakamura, S. et al. (2013) Mol Carcinog 52, 57-69.
  8. He, J. et al. (2011) Blood 117, 3869-80.

Application References

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