Product Pathways - Apoptosis
Cleaved Caspase-7 (Asp198) (D6H1) Rabbit mAb (PE Conjugate) #42542
|42542S||100 µl ( 50 tests )||￥4,060.00 现货查询||购买询价|
|42542||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: F=Flow Cytometry,
Specificity / Sensitivity
Cleaved Caspase-7 (Asp198) (D6H1) Rabbit mAb (PE Conjugate) recognizes endogenous levels of caspase-7 protein only when cleaved at Asp198.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp198 of human caspase-7 protein.
This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated Cleaved Caspase-7 (Asp198) (D6H1) Rabbit mab #8438.
Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis (1-4). Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP (1,3). During apoptosis, caspase-7 is activated through proteolytic processing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits (1,3). Similar to caspase-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD (5).
- Fernandes-Alnemri, T. et al. (1995) Cancer Res 55, 6045-52.
- Duan, H. et al. (1996) J Biol Chem 271, 1621-5.
- Lippke, J.A. et al. (1996) J Biol Chem 271, 1825-8.
- Cohen, G.M. (1997) Biochem J 326 ( Pt 1), 1-16.
- Thornberry, N.A. et al. (1997) J Biol Chem 272, 17907-11.
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For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
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