Cell Signaling Technology

Product Pathways - Metabolism

FABP5 (D1A7T) Rabbit mAb #39926

No. Size Price
39926S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
39926 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat, Endogenous 15 Rabbit IgG
IHC-P 1:1200

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IHC-P=Immunohistochemistry (Paraffin),

Specificity / Sensitivity

FABP5 (D1A7T) Rabbit mAb recognizes endogenous levels of total FABP5 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human FABP5 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using FABP5 (D1A7T) Rabbit mAb (upper) and GAPDH (D16H11) XP® Rabbit mAb (#5174), (lower). As expected, A172 cells are negative for FABP5.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded HCT 116 (left) and A172 (right) cell pellets using FABP5 (D1A7T) Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human small intestine using FABP5 (D1A7T) Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human skin using FABP5 (D1A7T) Rabbit mAb.

Background

Fatty acid binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones (1). They participate in the transport of fatty acids and other lipids to various cellular pathways (1). They are critical mediators of metabolic processes, and are increasingly being understood to play key roles in disease (2). FABP5 is known as the epidermal fatty acid binding protein as it was originally identified in studies on psoriasis (3) where it was shown to play a role a role in keratinocyte differentiation (4). It has since been found to play diverse roles in other normal physiological processes as well as in disease states (5).

  1. Haunerland, N.H. and Spener, F. (2004) Prog Lipid Res 43, 328-49.
  2. Hotamisligil, G.S. and Bernlohr, D.A. (2015) Nat Rev Endocrinol 11, 592-605.
  3. Madsen, P. et al. (1992) J Invest Dermatol 99, 299-305.
  4. Siegenthaler, G. et al. (1994) Biochem J 302 ( Pt 2), 363-71.
  5. Thumser, A.E. et al. (2014) Curr Opin Clin Nutr Metab Care 17, 124-9.

Application References

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Protocols

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For Research Use Only. Not For Use In Diagnostic Procedures.

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