Cell Signaling Technology

Product Pathways - Neuroscience

PSD95 (7E3) Mouse mAb #36233


No. Size Price
36233S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
36233 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat, Endogenous 95 Mouse IgG1
IF-F 1:100
IF-IC 1:100

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IF-F=Immunofluorescence (Frozen), IF-IC=Immunofluorescence (Immunocytochemistry),

Specificity / Sensitivity

PSD95 (7E3) Mouse mAb recognizes endogenous levels of total PSD95 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the full length rat PSD95 protein.



Confocal immunofluorescent analysis of mouse primary neurons using PSD95 (7E3) Mouse mAb (green) and Synapsin-1 (D12G5) XP® Rabbit mAb #5297 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).



Confocal immunofluorescent analysis of rat retina using PSD95 (7E3) Mouse mAb (green) and Secretagogin (D4V1Y) XP® Rabbit mAb #14037 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

Western Blotting

Western Blotting

Western blot analysis of extracts from various tissues using PSD95 (7E3) Mouse mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).


Postsynaptic Density protein 95 (PSD95) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. These family members consist of an amino-terminal variable segment followed by three PDZ domains, a SH3 domain, and an inactive guanylate kinase (GK) domain. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex (1-2). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (3). It is implicated in experience-dependent plasticity and plays an indispensable role in learning (4). Mutations in PSD95 are associated with autism (5).

  1. Cao, J. et al. (2005) J. Cell Biol 168, 117-26.
  2. Chetkovich, D.M. et al. (2002) J. Neurosci. 22, 6415-25.
  3. Cai, C. et al. (2006) J. Biol. Chem. 281, 4267-73.
  4. Yao, W.D. et al. (2004) Neuron 41, 625-38.
  5. Cline, H. (2005) Curr. Biol. 15, R203-5.

Application References

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