Product Pathways - Metabolism
SNAT1/SLC38A1 (D9L2P) Rabbit mAb #36057
|36057S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|36057||carrier free & custom formulation / quantity||email request|
|W||1:1000||Human,Mouse,Rat,||Endogenous||50, 70||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
SNAT1/SLC38A1 (D9L2P) Rabbit mAb recognizes endogenous levels of total SNAT1/SLC38A1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly37 of human SNAT1/SLC38A1 protein.
Western blot analysis of extracts from various brain samples and cell lines using SNAT1/SLC38A1 (D9L2P) Rabbit mAb.
Immunoprecipitaion of SNAT1/SLC38A1 from BT-549 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is SNAT1/SLC38A1 (D9L2P) Rabbit mAb. Western blot analysis was performed using SNAT1/SLC38A1 (D9L2P) Rabbit mAb and Mouse Anti-rabbit IgG (Conformation Specific) (L27A9) mAb #3678.
SNAT1/SLC38A1 belongs to the system A transporters that mediate Na+-dependent transport of short-chain neutral amino acids such as alanine, serine, and glutamine. SNAT1
/SLC38A1 mediates the uptake of glutamine in neurons and plays a crucial role in glutamate-glutamine cycle. Steep concentration gradients across the plasma membrane are achieved by coupling of the electrochemical sodium gradient to amino acid transport. This allows a unidirectional mode of transport for SNAT1/SLC38A1. Upregulation of SNAT1/SLC38A1 by neurotrophic factors is key to dendritic growth and branching of cortical neurons. High expression of SNAT1/SLC38A1 is found in cerebral cortex primarily in neurons and to a lesser extent in astrocytes (1-4). Elevated SNAT1/SLC38A1 expression is prominent in human solid tumors including gliomas, hepatocellular carcinomas and human breast cancer (5-8). Research studies show that an aberrant SNAT1
/SLC38A1 expression profile correlates with solid tumor recurrence and poor prognosis in patients with cholangiocarcinoma (9).
- Yao, D. et al. (2000) J Biol Chem 275, 22790-7.
- Mackenzie, B. et al. (2003) J Biol Chem 278, 23720-30.
- Chaudhry, F.A. et al. (2002) J Cell Biol 157, 349-55.
- Yu, W.L. et al. (2011) J Surg Res 171, 663-8.
- Melone, M. et al. (2004) Cereb Cortex 14, 562-74.
- Kondoh, N. et al. (2007) Int J Oncol 31, 81-7.
- Sidoryk, M. et al. (2004) Neuroreport 15, 575-8.
- Wang, K. et al. (2013) BMC Cancer 13, 343.
- Burkhalter, J. et al. (2007) J Biol Chem 282, 5152-9.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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