Cell Signaling Technology

Product Pathways - Chromatin Regulation / Epigenetics

PHF2 (D45A2) Rabbit mAb #3497

GRC5   KIAA0662   PHD   PHF finger   PHF Finger Protein 2  

No. Size Price
3497S 100 µl ( 10 western blots ) ¥3,250.00 现货查询 购买询价 防伪查询
3497T 20 µl ( 2 western blots ) ¥1,200.00 现货查询 购买询价 防伪查询
3497 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat,Monkey, Endogenous 150 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

PHF2 (D45A2) Rabbit mAb detects endogenous levels of total PHF2 protein.

PHF2 (D45A2) Rabbit mAb兔单抗能够检测内源性PHF2总蛋白水平。

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the human PHF2 protein.


Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using PHF2 (D45A2) Rabbit mAb.

使用PHF2 (D45A2) Rabbit mAb,免疫印迹(Western blot)分析不同细胞中PHF2 (D45A2)的蛋白水平。


Plant homeodomain (PHD) finger protein 2 (PHF2) is a putative transcription factor. PHF2 contains a zinc finger-like PHD domain that is distinct from other classes of zinc finger motifs and is often found in proteins that influence chromatin structure (1). It also contains a Jumonji C (JmjC) domain, which may play a role in histone demethylation (2). The PHF2 gene is ubiquitously expressed in adult mouse tissues; however, the majority of PHF2 expression in the mouse embryo occurs in the neural tube and root ganglia (1). PHF2 mutations have been associated with both early- and late-onset breast carcinoma (3).

Plant homeodomain (PHD) finger protein 2 (PHF2)是一个转录因子。PHF2包含一个锌指样PHD结构域,它与其它锌指结构有明显区别,并且经常发现在影响染色质结构的蛋白质中(1)。它也包含一个Jumonji C (JmjC)结构域,它可能在组蛋白去甲基化中起着重要作用(2)。PHF2基因在成年小鼠组织中广泛表达;然而,在小鼠胚胎中多数PHF2蛋白表达发生在神经管和根神经节(1)。PHF2突变是与早期和晚期乳腺癌有关联(3)。

  1. Hasenpusch-Theil, K. et al. (1999) Mamm Genome 10, 294-8.
  2. Klose, R.J. et al. (2006) Nat Rev Genet 7, 715-27.
  3. Sinha, S. et al. (2008) Mol Cancer 7, 84.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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