Cell Signaling Technology

Product Pathways - Metabolism

HMOX2/HO-2 (D9J9U) Rabbit mAb #32790

heme oxygenase (decycling) 2   Heme oxygenase 2   HMOX2   HO-2   HO2  

No. Size Price
32790S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
32790 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat,Hamster,Monkey, Endogenous 36 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

HMOX2/HO-2 (D9J9U) Rabbit mAb recognizes endogenous levels of total HMOX2/HO-2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala131 of human HMOX2/HO-2 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines and mouse testes using HMOX2/HO-2 (D9J9U) Rabbit mAb.

Background

Heme oxygenases (HMOX or HO) catalyze the rate-limiting step of the oxidative degradation of heme into iron, carbon monoxide, and biliverdin (1). Biliverdin is then converted to bilirubin (2). Heme is a strong pro-oxidant whereas bilirubin is a strong antioxidant (2). Research studies suggest disregulation of heme oxygenases may contribute to oxidative stress-related diseases (2). There are three isozymes of heme oxygenases: HMOX1/HO-1, HMOX2/HO-2, and HMOX3/HO-3 (1,2). HMOX1/HO-1 is inducible by heme and other stress stimuli (1,3). HMOX2/HO-2 and HMOX3/HO-3 are constitutively expressed (1,3).

  1. Piotrkowski, B. et al. (2009) J Endocrinol 203, 155-65.
  2. Synowiec, E. et al. (2012) Mol Biol Rep 39, 2081-7.
  3. Otterbein, L.E. and Choi, A.M. (2000) Am J Physiol Lung Cell Mol Physiol 279, L1029-37.

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For Research Use Only. Not For Use In Diagnostic Procedures.

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