Cell Signaling Technology

Product Pathways - Nuclear Receptor Signaling

Androgen Receptor Antibody #3202

AR   receptor  

No. Size Price
3202S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
3202 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 110 Rabbit

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,

Specificity / Sensitivity

Androgen Receptor Antibody detects endogenous levels of total androgen receptor.Androgen Receptor Antibody能够检测内源性水平总的雄激素受体。

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser213 of human androgen receptor. Antibodies are purified by protein A and peptide affinity chromatography.该多克隆抗体通过用合成肽免疫动物制备,该合成肽是人雄激素受体丝氨酸(213位)附近的残基。抗体由蛋白A和肽亲和层析纯化。

Western Blotting

Western Blotting

Western blot analysis of extracts from LNCaP cells using Androgen Receptor Antibody.Western blot方法检测LNCaP细胞提取物,使用的抗体为Androgen Receptor Antibody.

Background

Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).雄激素受体(AR)是锌指转录因子,属于核受体超家族,通过磷酸化和配体结合的二聚化被激活(1)。这促进了细胞核定位和雄激素靶基因中雄激素与应答元件的结合。 AR在男性发育和前列腺癌发展的几个阶段起着至关重要的作用(2,3)。

  1. Li, J. and Al-Azzawi, F. (2009) Maturitas 63, 142-8.
  2. Avila, D.M. et al. (2001) J. Steroid. Biochem. Mol. Biol. 76, 135-142.
  3. Montgomery, J.S. et al. (2001) J. Pathol. 195, 138-146.

Application References

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Protocols

Companion Products


For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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