Product Pathways - Metabolism
OGT (D1D8Q) Rabbit mAb #24083
FLJ23071 HRNT1 MGC22921 O-GLCNAC O-GlcNAc transferase p110 subunit O-GlcNAc transferase subunit p110 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) O-linked N-acetylglucosamine transferase 110 kDa subunit OGT OGT1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
|24083S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|24083||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
OGT (D1D8Q) Rabbit mAb recognizes endogenous levels of total OGT protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro546 of human OGT protein.
O-GlcNAcylation is a post-translational modification where β-D-N-acetylglucosamine (GlcNAc) is covalently linked to cytoplasmic and nuclear proteins at serine or threonine residues (1,2). This modification is important in many cellular processes including metabolism, cell growth and morphogenesis, apoptosis, and transcription (2,3), and research studies have implicated this modification in cancer (1). The reversible protein modification by O-GlcNAc, which has been suggested to be a nutrient and stress sensor, is catalyzed by two highly conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) (4).
- Comer, F.I. et al. (2001) Anal Biochem 293, 169-77.
- Slawson, C. and Hart, G.W. (2011) Nat Rev Cancer 11, 678-84.
- Capotosti, F. et al. (2011) Cell 144, 376-88.
- Hart, G.W. et al. (2007) Nature 446, 1017-22.
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