Cell Signaling Technology

Product Pathways - Metabolism

PANK1 (D2W3N) Rabbit mAb #23887

hPanK   hPanK1   MGC24596   PANK   PANK1   PANK1a   PANK1b   Pantothenate kinase 1   Pantothenic acid kinase 1  

No. Size Price
23887S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
23887 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Monkey, Endogenous 50 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

PANK1 (D2W3N) Rabbit mAb recognizes endogenous levels of total PANK1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro153 of human PANK1 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using PANK1 (D2W3N) Rabbit mAb.



Immunoprecipitation of PANK1 from Hep G2 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is PANK1 (D2W3N) Rabbit mAb. Western blot analysis was performed using PANK1 (D2W3N) Rabbit mAb. Mouse Anti-rabbit IgG (Light-Chain Specific) (L57A3) mAb #3677 was used as the secondary antibody.


Pantothenate kinase 1 (PANK1) is the rate-limiting enzyme in coenzyme A (CoA) synthesis (1,2). PPARα -mediated transcriptional regulation of PANK1 plays an important role in controlling CoA levels in hepatocytes (1). Research studies indicate that PANK1 expression, along with microRNA-107, decreases in a murine macrophage model upon lipopolysaccharide (LPS) exposure in a PPARα-dependent manner (3). Additional studies show that the corresponding PANK1 gene is a direct target of tumor suppressor p53 and that p53 regulates energy homeostasis through control of PANK1 expression (2).

  1. Ramaswamy, G. et al. (2004) J Lipid Res 45, 17-31.
  2. Wang, S.J. et al. (2013) Cell Cycle 12, 753-61.
  3. Hennessy, E.J. et al. (2011) J Biol Chem 286, 25531-9.

Application References

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