Product Pathways - Metabolism
PANK1 (D2W3N) Rabbit mAb #23887
|23887S||100 µl ( 10 western blots )||￥3,250.00 现货查询||购买询价|
|23887||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
PANK1 (D2W3N) Rabbit mAb recognizes endogenous levels of total PANK1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro153 of human PANK1 protein.
Western blot analysis of extracts from various cell lines using PANK1 (D2W3N) Rabbit mAb.
Immunoprecipitation of PANK1 from Hep G2 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is PANK1 (D2W3N) Rabbit mAb. Western blot analysis was performed using PANK1 (D2W3N) Rabbit mAb. Mouse Anti-rabbit IgG (Light-Chain Specific) (L57A3) mAb #3677 was used as the secondary antibody.
Pantothenate kinase 1 (PANK1) is the rate-limiting enzyme in coenzyme A (CoA) synthesis (1,2). PPARα -mediated transcriptional regulation of PANK1 plays an important role in controlling CoA levels in hepatocytes (1). Research studies indicate that PANK1 expression, along with microRNA-107, decreases in a murine macrophage model upon lipopolysaccharide (LPS) exposure in a PPARα-dependent manner (3). Additional studies show that the corresponding PANK1 gene is a direct target of tumor suppressor p53 and that p53 regulates energy homeostasis through control of PANK1 expression (2).
- Ramaswamy, G. et al. (2004) J Lipid Res 45, 17-31.
- Wang, S.J. et al. (2013) Cell Cycle 12, 753-61.
- Hennessy, E.J. et al. (2011) J Biol Chem 286, 25531-9.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
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