Cell Signaling Technology

Product Pathways - Adhesion

MUC1 (D9O8K) XP® Rabbit mAb (PE Conjugate) #19926

No. Size Price
19926S 100 µl ( 50 tests ) ¥4,264.00 现货查询 购买询价
19926 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
F 1:50 Human, Endogenous Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: F=Flow Cytometry,

Specificity / Sensitivity

MUC1 (D9O8K) XP® Rabbit mAb (PE Conjugate) detects endogenous levels of total MUC1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human MUC1 protein.


This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated MUC1 (D9O8K) XP® Rabbit mAb #14161.

Flow Cytometry

Flow Cytometry

Flow cytometric analysis of HCT 116 (blue) and ZR-75-1 (green) cells using MUC1 (D9O8K) XP® Rabbit mAb (PE Conjugate).


Mucins represent a family of glycoproteins characterized by repeat domains and dense O-glycosylation (1). MUC1 (or mucin 1) is aberrantly overexpressed in most human carcinomas. Increased expression of MUC1 in carcinomas reduces cell-cell and cell-ECM interactions. MUC1 is cleaved proteolytically, and the large ectodomain can remain associated with the small 25 kDa carboxy-terminal domain that contains a transmembrane segment and a 72-residue cytoplasmic tail (1). MUC1 interacts with ErbB family receptors and potentiates ERK1/2 activation (2). MUC1 also interacts with β-catenin, which is regulated by GSK-3β, PKCγ, and Src through phosphorylation at Ser44, Thr41, and Tyr46 of the MUC1 cytoplasmic tail (3-5). Overexpression of MUC1 potentiates transformation (6) and attenuates stress-induced apoptosis through the Akt or p53 pathways (7,8).

  1. Baldus, S.E. et al. (2004) Crit Rev Clin Lab Sci 41, 189-231.
  2. Schroeder, J.A. et al. (2001) J Biol Chem 276, 13057-64.
  3. Li, Y. et al. (1998) Mol Cell Biol 18, 7216-24.
  4. Li, Y. et al. (2001) J Biol Chem 276, 6061-4.
  5. Ren, J. et al. (2002) J Biol Chem 277, 17616-22.
  6. Schroeder, J.A. et al. (2004) Oncogene 23, 5739-47.
  7. Raina, D. et al. (2004) J Biol Chem 279, 20607-12.
  8. Wei, X. et al. (2005) Cancer Cell 7, 167-78.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

XP is a registered trademark of Cell Signaling Technology, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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