Cell Signaling Technology

Product Pathways - Neuroscience

PSD93 (D4Z4D) Rabbit mAb #19046

No. Size Price
19046S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
19046 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat, Endogenous 110 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

PSD93 (D4Z4D) Rabbit mAb recognizes endogenous levels of total PSD93 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro321 of human PSD93 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from rat and mouse brain using PSD93 (D4Z4D) Rabbit mAb.

IP

IP

Immunoprecipitation of PSD93 from mouse brain extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is PSD93 (D4Z4D) Rabbit mAb. Western blot analysis was performed using PSD93 (D4Z4D) Rabbit mAb.

Background

Postsynaptic Density Protein 93 (PSD93) is a member of the PSD subfamily of the membrane-associated guanylate kinase (PSD-MAGUK) proteins. Structurally, it most closely resembles PSD95, consisting of an N-terminal variable segment followed by three PDZ domains, an SH3 domain, and an inactive guanylate kinase (GK) domain (1,2). PSD93 is expressed in neuronal cells and located at the synapse where it interacts with neuronal receptors and proteins including the NMDA receptor (2-4), K+ channels (5,6), and the AMPA receptor (7) to regulate their membrane localization and neuronal signaling. Research studies have implicated PSD93 in postsynaptic related persistent pain induction, making PSD93 a potential target for treatment of this syndrome (3).

  1. Brenman, J.E. et al. (1996) J Neurosci 16, 7407-15.
  2. Kim, E. et al. (1996) Neuron 17, 103-13.
  3. Tao, Y.X. et al. (2003) J Neurosci 23, 6703-12.
  4. Niethammer, M. et al. (1996) J Neurosci 16, 2157-63.
  5. Kim, E. et al. (1995) Nature 378, 85-8.
  6. Leyland, M.L. and Dart, C. (2004) J Biol Chem 279, 43427-36.
  7. Elias, G.M. et al. (2006) Neuron 52, 307-20.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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