Product Pathways - Neuroscience
RGS4 (D4V1P) Rabbit mAb #15129
|15129S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|15129||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
RGS4 (D4V1P) Rabbit mAb recognizes endogenous levels of total RGS4 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human RGS4 protein.
Western blot analysis of extracts from mouse brain and rat brain using RGS4 (D4V1P) Rabbit mAb.
Regulators of G protein signaling (RGS) are a family of about 40 proteins that determine the signaling amplitude and duration of G protein-coupled receptor signaling via modulation of the GTPase activity of G proteins (1-3). Each RGS has a distinct structure, expression pattern, and regulation, resulting in preferential interactions with receptors, G proteins, and other signaling proteins, as well as a unique function (4).
Regulator of G-protein signaling 4 (RGS4) is a small RGS (23 kDa) that belongs to the R4 subfamily of heterotrimeric G-protein regulators. RGS4 contains a short amino-terminus that may be responsible for its functional specificity towards G-protein-coupled receptors, and a conserved RGS domain responsible for GAP activity (1). The RGS4 protein shares activity at both Gαq and Gαi/o proteins (5,6). Degradation of RGS4 is regulated by opioid receptor-mediated ubiquitination following stimulation by opioid receptor agonists, such as the DAMGO synthetic opioid peptide (7). RGS4 modulates the action of morphine and other opiates in vivo (8).
- Hollinger, S. and Hepler, J.R. (2002) Pharmacol Rev 54, 527-59.
- Traynor, J.R. and Neubig, R.R. (2005) Mol Interv 5, 30-41.
- Neubig, R.R. and Siderovski, D.P. (2002) Nat Rev Drug Discov 1, 187-97.
- Terzi, D. et al. (2009) Prog Mol Biol Transl Sci 86, 299-333.
- Xu, X. et al. (1999) J Biol Chem 274, 3549-56.
- Berman, D.M. et al. (1996) Cell 86, 445-52.
- Wang, Q. and Traynor, J.R. (2011) J Biol Chem 286, 7854-64.
- Han, M.H. et al. (2010) Biol Psychiatry 67, 761-9.
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