Product Pathways - Neuroscience
Rhodopsin (D1N7X) Rabbit mAb #14825
|14825S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|14825||carrier free & custom formulation / quantity||email request|
|W||1:1000||Mouse,Rat,||Endogenous||37, 75, 150||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Species predicted to react based on 100% sequence homology: Human,
Specificity / Sensitivity
Rhodopsin (D1N7X) Rabbit mAb recognizes endogenous levels of total rhodopsin protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human rhodopsin protein.
Western blot analysis of extracts from mouse eye, mouse lung, and rat eye using Rhodopsin (D1N7X) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
Rhodopsin is the photoreceptor in the retinal rods. It is activated by photons, transduces visual information through its cognate G protein, transducin, and is inactivated by arrestin binding (1). Using atomic-force microscopy, rhodopsin was found to be arranged into paracrystalline arrays of dimers in mouse disc membranes (2). Rhodopsin is considered to be the prototype of G protein-coupled receptors (GPCRs), and is the first GPCR for which a crystal structure was solved (3). Research studies have linked mutations in the gene encoding rhodopsin to retinitis pigmentosa (4,5), a disease characterized by retinal degeneration resulting in reduced peripheral vision and night blindness (6).
- Arshavsky, V.Y. and Burns, M.E. (2012) J Biol Chem 287, 1620-6.
- Fotiadis, D. et al. (2003) Nature 421, 127-8.
- Palczewski, K. et al. (2000) Science 289, 739-45.
- Rivolta, C. et al. (2002) Hum Mol Genet 11, 1219-27.
- Wilson, J.H. and Wensel, T.G. (2003) Mol Neurobiol 28, 149-58.
- Hartong, D.T. et al. (2006) Lancet 368, 1795-809.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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