Cell Signaling Technology

Product Pathways - Chromatin Regulation / Epigenetics

PRMT7 (D1K6R) Rabbit mAb #14762

methyltransferase   PRMT  

No. Size Price
14762S 100 µl ( 10 western blots ) ¥3,100.00 现货查询 购买询价
14762 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Monkey, Endogenous 78 Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting,


Species predicted to react based on 100% sequence homology: Bovine,

Specificity / Sensitivity

PRMT7 (D1K6R) Rabbit mAb recognizes endogenous levels of total PRMT7 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val233 of human PRMT7 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using PRMT7 (D1K6R) Rabbit mAb.


Protein arginine N-methyltransferase 7 (PRMT7) is a member of the protein arginine N-methyltransferase (PRMT) family of proteins that catalyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) to a guanidine nitrogen of arginine (1). The three types of PRMTs share the ability to mono-methylate arginine residues, but vary in their ability to generate differential methylation states (1-3). Mono-methylated arginine residues are further methylated by type I PRMTs to generate an asymmetric di-methyl arginine or by type II PRMTs to form a symmetric-dimethyl arginine. Type III methyltransferases are only able to mono-methylate arginine residues (1-3). Research studies indicate that PRMT7 is a type III PRMT that displays substrate specificity for an arginine-X-arginine (RXR) motif surrounded by several basic residues (4,5). PRMT7 interacts with a wide array of protein substrates and likely plays a role in many biological processes including pluripotency, neuronal differentiation, genomic instability, snRNP biogenesis, and breast cancer metastasis (6-11).

  1. Di Lorenzo, A. and Bedford, M.T. (2011) FEBS Lett 585, 2024-31.
  2. Yang, Y. and Bedford, M.T. (2013) Nat Rev Cancer 13, 37-50.
  3. Molina-Serrano, D. et al. (2013) Biochem Soc Trans 41, 751-9.
  4. Feng, Y. et al. (2013) J Biol Chem 288, 37010-25.
  5. Feng, Y. et al. (2014) J Biol Chem 289, 32604-16.
  6. Buhr, N. et al. (2008) Electrophoresis 29, 2381-90.
  7. Dhar, S.S. et al. (2012) Genes Dev 26, 2749-62.
  8. Verbiest, V. et al. (2008) FEBS Lett 582, 1483-9.
  9. Gros, L. et al. (2003) Cancer Res 63, 164-71.
  10. Gros, L. et al. (2006) Biochim Biophys Acta 1760, 1646-56.
  11. Gonsalvez, G.B. et al. (2007) J Cell Biol 178, 733-40.

Application References

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