Product Pathways - Lymphocyte Signaling
β2-microglobulin (D8P1H) Rabbit mAb (PE Conjugate) #14730
|14730S||100 µl ( 50 tests )||￥3,876.00 现货查询||购买询价|
|14730||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: F=Flow Cytometry,
Specificity / Sensitivity
β2-microglobulin (D8P1H) Rabbit mAb recognizes endogenous levels of total β2-microglobulin protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp79 of human β2-microglobulin protein.
This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated β2-microglobulin (D8P1H) Rabbit mAb #12851.
β2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system (1,2). As an integral component of the MHC class I complex, β2-microglobulin plays a critically important role in immune system function (3). It has important relevance to cancer biology research; for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, thereby allowing tumor cells to escape immune detection (4). In addition, β2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity (5); its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy (6).
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- Collins, E.J. et al. (1995) Proc Natl Acad Sci U S A 92, 1218-21.
- Marx, J.I. (1974) Science 185, 428-9.
- Challa-Malladi, M. et al. (2011) Cancer Cell 20, 728-40.
- Gorevic, P.D. et al. (1985) J Clin Invest 76, 2425-9.
- Ohashi, K. (2001) Pathol Int 51, 1-10.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
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